野生型tsA突变猿猴病毒40转化的细胞系中肿瘤特异性移植抗原的表达
Expression of tumor-specific transplantation antigen in cell lines transformed by wild-type of tsA mutant simian virus 40.
作者信息
Chang C, Anderson J L, Martin R G, Mora P T
出版信息
J Virol. 1977 May;22(2):281-9. doi: 10.1128/JVI.22.2.281-289.1977.
Abstract
The simian virus 40-induced tumor-specific surface antigen(s) (TSSA) and tumor-specific transplantation antigen(s) (TSTA)were detected in cells transformed by wild-type or temperature-sensitive mutant simian virus 40 by an antibody-mediated cytolytic assay for TSSA and an immunization test for TSTA. Cells transformed by tsA mutants, which lose their transformed phenotype when grown at nonpermissive temperatures, nonetheless do express TSSA and TSTA as well as T-antigen at both temperatures.
摘要
通过针对猿猴病毒40诱导的肿瘤特异性表面抗原（TSSA）的抗体介导细胞溶解试验和针对肿瘤特异性移植抗原（TSTA）的免疫试验，在野生型或温度敏感型突变猿猴病毒40转化的细胞中检测到了TSSA和TSTA。tsA突变体转化的细胞在非允许温度下生长时会失去其转化表型，但在两种温度下均能表达TSSA、TSTA以及T抗原。
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