Hsiao Hsien-Yi, Chen Richie L C, Cheng Tzong-Jih
Department of Bio-industrial Mechatronics Engineering, College of Bio-Resources and Agriculture, National Taiwan University, Taipei 106, Taiwan.
Rev Sci Instrum. 2009 Apr;80(4):044301. doi: 10.1063/1.3111402.
This work presents a method for sensing the viscoelastic property of liquid/solid interface using a quartz crystal microbalance (QCM) array. Each sensor in a QCM array has a unique resonant frequency and can be identified by a single-scan measurement of admittance (or impedance). The resonant frequency encoding at each sensor in an array was realized by connecting a capacitor with a known capacitance, called a resonant marker, to the sensor in series. Changes in the resonant frequency of all sensors in an array can be determined using an impedance analyzer and a program that determines the frequencies at which the conductance is at a local maximum. The sensing method allows every sensor output (resonant frequency) to be obtained without the use of time-consuming multiplexed hardware and software. Adsorptions of biomolecules by multiple sensor are monitored in the liquid phase to demonstrate the feasibility of frequency encoding using resonant markers and the single-scan measurement of conductance of a QCM array.
这项工作提出了一种使用石英晶体微天平（QCM）阵列来传感液/固界面粘弹性特性的方法。QCM阵列中的每个传感器都有一个独特的共振频率，并且可以通过导纳（或阻抗）的单次扫描测量来识别。通过将一个具有已知电容的电容器（称为共振标记）串联到传感器上，实现了阵列中每个传感器的共振频率编码。可以使用阻抗分析仪和一个确定电导处于局部最大值时频率的程序来确定阵列中所有传感器共振频率的变化。这种传感方法无需使用耗时的多路复用硬件和软件就能获得每个传感器的输出（共振频率）。在液相中监测多个传感器对生物分子的吸附，以证明使用共振标记进行频率编码和QCM阵列电导单次扫描测量的可行性。
