Kerr Carolyn L, Bouré Ludovic P, Pearce Simon G, McDonell Wayne N
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada.
Am J Vet Res. 2009 May;70(5):574-80. doi: 10.2460/ajvr.70.5.574.
To evaluate cardiopulmonary effects of anesthetic induction with diazepam and ketamine or xylazine and ketamine, with subsequent maintenance of anesthesia with isoflurane, in foals undergoing abdominal surgery.
17 pony foals.
Foals underwent laparotomy at 7 to 15 days of age and laparoscopy 7 to 10 days later. Foals were randomly assigned to receive diazepam, ketamine, and isoflurane (D/K/Iso; n = 8) or xylazine, ketamine, and isoflurane (X/K/Iso; 9) for both procedures.
During anesthesia for laparotomy, cardiac index, and mean arterial blood pressure ranged from 110 to 180 mL/kg/min and 57 to 81 mm Hg, respectively, in the D/K/Iso group and 98 to 171 mL/kg/min and 50 to 66 mm Hg, respectively, in the X/K/Iso group. Cardiac index, heart rate, and arterial blood pressures were significantly higher in the D/K/Iso group, compared with the X/K/Iso group. During anesthesia for laparoscopy, cardiac index and mean arterial blood pressure ranged from 85 to 165 mL/kg/min and 67 to 83 mm Hg, respectively, in the D/K/Iso group, and 98 to 171 mL/kg/min and 48 to 67 mm Hg, respectively, in the X/K/Iso group. Heart rates and arterial blood pressures were significantly higher in the D/K/Iso group, compared with the X/K/Iso group. There were no significant differences between groups during either experimental period for percentage end-tidal isoflurane, arterial blood gas partial pressures, or pH values.
Anesthesia of foals for abdominal surgery with D/K/Iso was associated with less hemodynamic depression than with X/K/Iso.
评估在接受腹部手术的幼驹中，使用地西泮和氯胺酮或赛拉嗪和氯胺酮进行麻醉诱导，并随后用异氟烷维持麻醉的心肺效应。
17匹小马驹。
幼驹在7至15日龄时接受剖腹术，7至10日后接受腹腔镜检查。两组手术中，幼驹被随机分配接受地西泮、氯胺酮和异氟烷（D/K/Iso组；n = 8）或赛拉嗪、氯胺酮和异氟烷（X/K/Iso组；n = 9）。
在剖腹术麻醉期间，D/K/Iso组的心脏指数和平均动脉血压分别为110至180毫升/千克/分钟和57至81毫米汞柱，X/K/Iso组分别为98至171毫升/千克/分钟和50至66毫米汞柱。与X/K/Iso组相比，D/K/Iso组的心脏指数、心率和动脉血压显著更高。在腹腔镜检查麻醉期间，D/K/Iso组的心脏指数和平均动脉血压分别为85至165毫升/千克/分钟和67至83毫米汞柱，X/K/Iso组分别为98至171毫升/千克/分钟和48至67毫米汞柱。与X/K/Iso组相比，D/K/Iso组的心率和动脉血压显著更高。在两个实验阶段，两组之间在呼气末异氟烷百分比、动脉血气分压或pH值方面均无显著差异。
与X/K/Iso相比，使用D/K/Iso对幼驹进行腹部手术麻醉时，血流动力学抑制较轻。
