Steffey Eugene P, Mama Khursheed R, Brosnan Robert J, Imai Ayako, Maxwell Lara K, Cole Cynthia A, Stanley Scott D
Department of Surgical and Radiological Sciences, School of Veterinary Medicine and KL Maddy Equine Analytical Chemistry Laboratory, California Animal Health and Food Safety Laboratory, University of California, Davis, CA 95616, USA.
Am J Vet Res. 2009 Aug;70(8):956-63. doi: 10.2460/ajvr.70.8.956.
To compare characteristics of horses recovering from 4 hours of desflurane anesthesia with and without immediate postanesthetic IV administration of propofol and xylazine. Animals-8 healthy horses (mean +/- SEM age, 6.6 +/- 1.0 years; mean body weight, 551 +/- 50 kg).
Horses were anesthetized twice. Both times, anesthesia was induced with a combination of xylazine hydrochloride, diazepam, and ketamine hydrochloride and then maintained for 4 hours with desflurane in oxygen. Choice of postanesthetic treatment was randomly assigned via a crossover design such that each horse received an IV injection of propofol and xylazine or saline (0.9% NaCl) solution after the anesthetic episode. Recovery events were quantitatively and qualitatively assessed. Venous blood samples were obtained before and after anesthesia for determination of serum creatine kinase activity and plasma propofol concentration.
Anesthetic induction and maintenance were unremarkable in all horses. Compared with administration of saline solution, postanesthetic administration of propofol and xylazine resulted in an increased interval to emergence from anesthesia but improved quality of recovery-related transition to standing. Compared with administration of saline solution, administration of propofol also delayed the rate of decrease of end-tidal concentrations of desflurane and carbon dioxide and added to conditions promoting hypoxemia and hypoventilation.
Propofol and xylazine administered IV to horses after 4 hours of desflurane anesthesia improved the quality of transition from lateral recumbency to standing but added potential for harmful respiratory depression during the postanesthetic period.
比较在麻醉后立即静脉注射丙泊酚和赛拉嗪与不注射的情况下，接受4小时地氟醚麻醉后恢复的马匹的特征。动物——8匹健康马匹（平均年龄±标准误，6.6±1.0岁；平均体重，551±50千克）。
马匹接受两次麻醉。两次麻醉均用盐酸赛拉嗪、地西泮和盐酸氯胺酮联合诱导，然后用氧气中的地氟醚维持麻醉4小时。通过交叉设计随机分配麻醉后治疗方案，使每匹马在麻醉期后接受静脉注射丙泊酚和赛拉嗪或生理盐水（0.9%氯化钠）溶液。对恢复事件进行定量和定性评估。在麻醉前后采集静脉血样，以测定血清肌酸激酶活性和血浆丙泊酚浓度。
所有马匹的麻醉诱导和维持均无异常。与给予生理盐水相比，麻醉后给予丙泊酚和赛拉嗪导致麻醉苏醒间隔时间延长，但改善了与恢复相关的站立过渡质量。与给予生理盐水相比，给予丙泊酚还延迟了地氟醚和二氧化碳呼气末浓度的下降速率，并增加了促进低氧血症和通气不足的情况。
地氟醚麻醉4小时后静脉注射丙泊酚和赛拉嗪可改善从侧卧到站立的过渡质量，但在麻醉后期间增加了有害呼吸抑制的可能性。
