[POEMS综合征：一例报告]

[POEMS syndrome: a case report].

作者信息

Mayayo Sinués E, Martínez García R, Felipó Berlanga F, Mazas Artasona L

机构信息

Servicio de Radiodiagnóstico, Hospital Universitario Miguel Servet, Zaragoza, Spain.

出版信息

Radiologia. 2009 Jul-Aug;51(4):424-7. doi: 10.1016/j.rx.2009.01.010. Epub 2009 Apr 29.

DOI:10.1016/j.rx.2009.01.010

PMID:19406440

Abstract

POEMS syndrome is a rare multisystemic disorder characterized by polyneuropathy (P), organomegaly (O), endocrinopathy (E), blood dyscrasia with M-protein band (M), and skin changes (S). The pathogenesis of POEMS syndrome is not completely understood. This paraneoplastic syndrome may be associated to bone lesions that are characteristically sclerotic or lytic with sclerotic halo and negative at bone scintigraphy. We report a case of a 37-year-old man with several manifestations of POEMS syndrome who presented bone lesions characteristic of osteosclerotic myeloma confirmed by bone biopsy.

摘要

POEMS综合征是一种罕见的多系统疾病，其特征为多发性神经病（P）、器官肿大（O）、内分泌病（E）、伴有M蛋白条带的血液系统异常（M）和皮肤改变（S）。POEMS综合征的发病机制尚未完全明确。这种副肿瘤综合征可能与骨病变有关，这些骨病变的特征是硬化性或溶解性伴硬化晕，且骨闪烁显像为阴性。我们报告一例37岁男性，具有POEMS综合征的多种表现，经骨活检证实存在骨硬化性骨髓瘤的特征性骨病变。