Lo Chun-Liang, Lin Sheng-Jie, Tsai Hsieh-Chih, Chan Wei-Hsiang, Tsai Cheng-Hung, Cheng Chien-Hsin D, Hsiue Ging-Ho
Department of Chemical Engineering, National Tsing Hua University, 101, Section 2, Kuang Fu Road, Hsinchu 300, Taiwan, ROC.
Biomaterials. 2009 Aug;30(23-24):3961-70. doi: 10.1016/j.biomaterials.2009.04.002. Epub 2009 Apr 29.
Mixed micelles formed by critical micelle concentration (Cmc) character's diblock copolymer, and temperature-sensitive character's diblock copolymer were studied for their capabilities in improving stability with and without drug. Experimental results showed that this type of mixed micellar systems possessed complementary effects in adjusting external temperature shift (storage vs. body temperature) and concentration change (dilution after intravenous injection). Therefore, they provided excellent stability as drug carriers. Further results obtained from physicochemical property and drug release kinetics studies demonstrated such systems could also be applied to physiological conditions, in compliance with varied pH environments. We concluded that the newly developed mixed micelles can serve as a potential injectable drug delivery system for anticancer drugs, such as doxorubicin and many others.
研究了由具有临界胶束浓度（Cmc）特性的两嵌段共聚物和具有温度敏感性特性的两嵌段共聚物形成的混合胶束在有无药物情况下提高稳定性的能力。实验结果表明，这类混合胶束系统在调节外部温度变化（储存温度与体温）和浓度变化（静脉注射后的稀释）方面具有互补作用。因此，它们作为药物载体具有出色的稳定性。从物理化学性质和药物释放动力学研究中获得的进一步结果表明，此类系统也可应用于生理条件，适应不同的pH环境。我们得出结论，新开发的混合胶束可作为阿霉素等多种抗癌药物的潜在注射用药物递送系统。
