Lee So Yun, Kang Moon Sung, Jeong Woo Yeup, Han Dong-Wook, Kim Ki Su
Department of Organic Materials Science and Engineering, College of Engineering, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan 46241, Korea.
Department of Cogno-Mechatronics Engineering, College of Nanoscience and Nanotechnology, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan 46241, Korea.
Cancers (Basel). 2020 Apr 10;12(4):940. doi: 10.3390/cancers12040940.
Hyaluronic acid (HA) is a natural mucopolysaccharide and has many useful advantages, including biocompatibility, non-immunogenicity, chemical versatility, non-toxicity, biodegradability, and high hydrophilicity. Numerous tumor cells overexpress several receptors that have a high binding affinity for HA, while these receptors are poorly expressed in normal body cells. HA-based drug delivery carriers can offer improved solubility and stability of anticancer drugs in biological environments and allow for the targeting of cancer treatments. Based on these benefits, HA has been widely investigated as a promising material for developing the advanced clinical cancer therapies in various formulations, including nanoparticles, micelles, liposomes, and hydrogels, combined with other materials. We describe various approaches and findings showing the feasibility of improvement in theragnosis probes through the application of HA.
透明质酸（HA）是一种天然的粘多糖，具有许多有益特性，包括生物相容性、非免疫原性、化学多功能性、无毒性、可生物降解性和高亲水性。许多肿瘤细胞过度表达几种对HA具有高结合亲和力的受体，而这些受体在正常体细胞中表达较少。基于HA的药物递送载体可以提高抗癌药物在生物环境中的溶解度和稳定性，并实现癌症治疗的靶向性。基于这些优点，HA已被广泛研究，作为一种有前景的材料，用于开发各种剂型（包括纳米颗粒、胶束、脂质体和水凝胶）与其他材料结合的先进临床癌症治疗方法。我们描述了各种方法和研究结果，展示了通过应用HA改进诊疗探针的可行性。
