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本文引用的文献

1
Elevated risk of chronic lymphocytic leukemia and other indolent non-Hodgkin's lymphomas among relatives of patients with chronic lymphocytic leukemia.慢性淋巴细胞白血病患者亲属患慢性淋巴细胞白血病及其他惰性非霍奇金淋巴瘤的风险升高。
Haematologica. 2009 May;94(5):647-53. doi: 10.3324/haematol.2008.003632. Epub 2009 Mar 13.
2
Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors.EB病毒和巨细胞病毒在一部分表达定型IGHV4-34 B细胞受体的慢性淋巴细胞白血病患者中持续存在的分子证据。
Leukemia. 2009 May;23(5):919-24. doi: 10.1038/leu.2008.379. Epub 2009 Jan 15.
3
Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.细胞凋亡和免疫调节相关基因的遗传变异与慢性淋巴细胞白血病的风险相关。
Cancer Res. 2008 Dec 15;68(24):10178-86. doi: 10.1158/0008-5472.CAN-08-2221.
4
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.一项全基因组关联研究确定了慢性淋巴细胞白血病的六个易感基因座。
Nat Genet. 2008 Oct;40(10):1204-10. doi: 10.1038/ng.219. Epub 2008 Aug 31.
5
Monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia.单克隆B细胞淋巴细胞增多症与慢性淋巴细胞白血病
N Engl J Med. 2008 Aug 7;359(6):575-83. doi: 10.1056/NEJMoa075290.
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Analysis of a large multi-generational family provides insight into the genetics of chronic lymphocytic leukemia.对一个大型多代家族的分析为慢性淋巴细胞白血病的遗传学研究提供了深入了解。
Br J Haematol. 2008 Jun;142(2):238-45. doi: 10.1111/j.1365-2141.2008.07188.x. Epub 2008 May 22.
7
Insight into the pathogenesis of chronic lymphocytic leukemia (CLL) through analysis of IgVH gene usage and mutation status in familial CLL.通过分析家族性慢性淋巴细胞白血病（CLL）中IgVH基因的使用情况和突变状态来深入了解其发病机制。
Blood. 2008 Jun 15;111(12):5691-3. doi: 10.1182/blood-2008-03-142349. Epub 2008 Apr 18.
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Interferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes.干扰素调节因子4参与爱泼斯坦-巴尔病毒介导的人B淋巴细胞转化。
J Virol. 2008 Jul;82(13):6251-8. doi: 10.1128/JVI.00163-08. Epub 2008 Apr 16.
9
A high-density SNP genome-wide linkage search of 206 families identifies susceptibility loci for chronic lymphocytic leukemia.对206个家庭进行的高密度单核苷酸多态性全基因组连锁搜索确定了慢性淋巴细胞白血病的易感基因座。
Blood. 2007 Nov 1;110(9):3326-33. doi: 10.1182/blood-2007-05-091561. Epub 2007 Aug 8.
10
Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia.慢性淋巴细胞白血病中死亡相关蛋白激酶1（DAPK1）的下调
Cell. 2007 Jun 1;129(5):879-90. doi: 10.1016/j.cell.2007.03.043.

家族性慢性淋巴细胞白血病的分子基础。

The molecular basis of familial chronic lymphocytic leukemia.

作者信息

Crowther-Swanepoel Dalemari, Houlston Richard S

出版信息

Haematologica. 2009 May;94(5):606-9. doi: 10.3324/haematol.2009.006296.

DOI:10.3324/haematol.2009.006296
PMID:19407315
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2675670/
Abstract

Our understanding of the genetic basis of chronic lymphocytic leukemia is only just starting to be recognized. This perspective article by Drs. Crowther-Swanepoel and Houlston provides an up-to-date review the molecular epidemiology of chronic lymphocytic leukemia, with emphasis on the integration of biology and genomics.

摘要

我们对慢性淋巴细胞白血病遗传基础的理解才刚刚开始得到认识。克劳瑟 - 斯瓦内普尔博士和豪尔斯顿博士撰写的这篇观点文章对慢性淋巴细胞白血病的分子流行病学进行了最新综述，重点在于生物学与基因组学的整合。