Hunting for the function of Huntingtin.
作者信息
Zheng Qi, Joinnides Mark
机构信息
Department of Biology, The University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Dis Model Mech. 2009 May-Jun;2(5-6):199-200. doi: 10.1242/dmm.003376.
Abstract
摘要
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Hunting for the function of Huntingtin.探寻亨廷顿蛋白的功能。
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本文引用的文献
1
Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington's disease model.果蝇亨廷顿蛋白的失活影响成年果蝇的长期功能以及亨廷顿舞蹈病模型的发病机制。
Dis Model Mech. 2009 May-Jun;2(5-6):247-66. doi: 10.1242/dmm.000653. Epub 2009 Apr 6.
2
Mechanisms of neurodegeneration in Huntington's disease.亨廷顿舞蹈症中的神经退行性变机制。
Eur J Neurosci. 2008 Jun;27(11):2803-20. doi: 10.1111/j.1460-9568.2008.06310.x.
3
Huntington's disease: from pathology and genetics to potential therapies.亨廷顿舞蹈病：从病理学、遗传学至潜在疗法
Biochem J. 2008 Jun 1;412(2):191-209. doi: 10.1042/BJ20071619.
4
Drosophila as a model for human neurodegenerative disease.果蝇作为人类神经退行性疾病的模型
Annu Rev Genet. 2005;39:153-71. doi: 10.1146/annurev.genet.39.110304.095804.
5
Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila.亨廷顿蛋白缺失或致病性多聚谷氨酰胺蛋白在果蝇中表达导致轴突运输中断。
Neuron. 2003 Sep 25;40(1):25-40. doi: 10.1016/s0896-6273(03)00594-4.
6
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila.组蛋白去乙酰化酶抑制剂可阻止果蝇中多聚谷氨酰胺依赖性神经变性。
Nature. 2001 Oct 18;413(6857):739-43. doi: 10.1038/35099568.
7
Loss of normal huntingtin function: new developments in Huntington's disease research.正常亨廷顿蛋白功能丧失：亨廷顿舞蹈症研究的新进展
Trends Neurosci. 2001 Mar;24(3):182-8. doi: 10.1016/s0166-2236(00)01721-5.
8
A putative Drosophila homolog of the Huntington's disease gene.亨廷顿舞蹈症基因的一个假定果蝇同源基因。
Hum Mol Genet. 1999 Sep;8(9):1807-15. doi: 10.1093/hmg/8.9.1807.
9
Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons.聚谷氨酰胺扩展的人类亨廷顿蛋白转基因诱导果蝇光感受器神经元退化。
Neuron. 1998 Sep;21(3):633-42. doi: 10.1016/s0896-6273(00)80573-5.
10
Polyglutamine expansion and Huntington's disease.聚谷氨酰胺扩增与亨廷顿舞蹈症
Biochem Soc Trans. 1998 Aug;26(3):471-5. doi: 10.1042/bst0260471.
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