Shukla Sanjeev, Pranay Atul, D'Cruz Anil K, Chaturvedi Pankaj, Kane Shubhada V, Zingde Surekha M
Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Navi Mumbai, India.
Cancer Biomark. 2009;5(3):127-35. doi: 10.3233/CBM-2009-0604.
Autoantibody response to tumor antigens has been widely used to identify novel tumor markers for different cancers, including that of the head and neck. The oral cavity, which is in the head and neck region, comprises of many sub sites with distinct biologies and incidence of cancer of each sub site of the oral cavity is different. It is anticipated therefore that each sub site of the oral cavity may elicit a differential autoantibody response. This report evaluates the autoantibody response in 15 patients with cancer of gingivo-buccal complex and in 15 patients with cancer of tongue using Immunoproteomics, and shows that the autoantibody response to alpha-enolase, HSP 70, peroxiredoxin-VI, annexin II, pyruvate kinase, alpha-tubulin, beta-tubulin, ATP synthase, triose phosphate isomerase and aldose reductase seen in patients with cancer of gingivo-buccal complex is absent in patients with cancer of tongue. This suggests that cancer of these sub sites should be studied separately because of their different biology and emerging site specific molecular signatures including autoantibody responses to ensure unambiguous clinical interpretations.
针对肿瘤抗原的自身抗体反应已被广泛用于识别不同癌症（包括头颈癌）的新型肿瘤标志物。口腔位于头颈区域，由许多亚部位组成，各亚部位具有不同的生物学特性，口腔各亚部位的癌症发病率也不同。因此可以预期，口腔的每个亚部位可能会引发不同的自身抗体反应。本报告使用免疫蛋白质组学评估了15例牙龈颊侧复合体癌患者和15例舌癌患者的自身抗体反应，结果显示，牙龈颊侧复合体癌患者体内针对α-烯醇化酶、热休克蛋白70、过氧化物酶体增殖物激活受体VI、膜联蛋白II、丙酮酸激酶、α-微管蛋白、β-微管蛋白、ATP合酶、磷酸丙糖异构酶和醛糖还原酶的自身抗体反应在舌癌患者中不存在。这表明，由于这些亚部位具有不同的生物学特性以及新出现的部位特异性分子特征（包括自身抗体反应），应对这些亚部位的癌症分别进行研究，以确保临床解释的明确性。
