Lopes Marilia Gabriela de Oliveira, Watanabe Ii-sei, Soares Luís Eduardo Silva, da Silva Newton Soares, da Silva Marcelo Cavenaghi Pereira
Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Gerontology. 2009;55(4):442-8. doi: 10.1159/000216829. Epub 2009 Apr 29.
There is general consensus that the effects of intrinsic aging on the oral mucosa are relatively small, though potentially important to understanding the pathologies present in the aged animals.
In this paper, the development of dorsal surface of rat tongue was examined using transmission electron microscopy (TEM) and high-resolution scanning electron microscopy (HRSEM) in order to understand the age-related structural and ultrastructural changes experimentally.
In this study, we used female rats 75 and 720 days old (adult and aging). Tissues of rat tongue were prepared and the specimens submitted to HRSEM and TEM techniques.
The analysis of HRSEM and TEM demonstrated that the same characteristic keratinous epithelium was found in aging animals, however with some modifications.
We agree that there are obvious changes in the oral mucosa with aging and these modifications can be observed starting from the ultrastructural aspects.
人们普遍认为，内在衰老对口腔黏膜的影响相对较小，尽管这对于理解老年动物中存在的病理学可能很重要。
在本文中，为了通过实验了解与年龄相关的结构和超微结构变化，使用透射电子显微镜（TEM）和高分辨率扫描电子显微镜（HRSEM）检查了大鼠舌背表面的发育情况。
在本研究中，我们使用了75天和720天大的雌性大鼠（成年和衰老）。制备大鼠舌组织，并将标本提交给HRSEM和TEM技术。
HRSEM和TEM分析表明，在衰老动物中发现了相同特征的角质化上皮，但有一些变化。
我们一致认为，随着年龄的增长，口腔黏膜会发生明显变化，并且这些变化可以从超微结构方面开始观察到。
