Small William, Du Bois Andreas, Bhatnagar Saurabha, Reed Nick, Pignata Sandro, Potter Richard, Randall Marcus, Mirza Monsoor, Trimble Edward, Gaffney David
RTOG, Philadelphia, PA, USA.
Int J Gynecol Cancer. 2009 Apr;19(3):395-9. doi: 10.1111/igc.0b013e3181a1cee8.
To describe radiotherapeutic practice of the treatment of endometrial cancer in members of the Gynecologic Cancer Intergroup (GCIG).
A survey was developed and distributed to the members of the GCIG. The GCIG is a global association of cooperative groups involved in the research and treatment of gynecologic neoplasms.
Thirty-four surveys were returned from 13 different cooperative groups. For the treatment of endometrial cancer after hysterectomy, mean (SD) pelvic dose was 47.37 (2.32) Gy. The upper border of the pelvic field was L4/5 in 14 respondents, L5/S1 in 13 respondents, and not specified in 6 surveys. When vaginal brachytherapy (VBT) was used in conjunction with external beam radiotherapy, most groups used high dose rate versus low dose rate on 24 versus 5 respondents, respectively. Twenty-eight of the 34 respondents performed computed tomographic simulation. Intensity-modulated radiotherapy was used routinely in 3 of the 34 respondents. For a para-aortic field, the upper border was, most commonly, at the T12-L1 interspace (17 of the 28 respondents), and the mean (SD) dose was 46.15 (2.18) Gy. For VBT alone after hysterectomy, 23 groups performed high-dose-rate brachytherapy (27.57 [10.13] Gy in a mean of 4.3 insertions), and 5 groups used low-dose-rate brachytherapy (41.45 [17.5] Gy). Nineteen of the 28 respondents measured the doses to the bladder and the rectum when performing VBT. For brachytherapy, there was no uniformity in the fraction of the vagina treated or the doses and schedules used.
Radiotherapy practices among member groups of the GCIG are similar in doses and dose per fraction with external beam. There is a moderate discrepancy in the brachytherapy practice after hysterectomy. There are no serious impediments to intergroup participation in radiation oncology practices among GCIG members with the use of external beam.
描述妇科肿瘤协作组（GCIG）成员对子宫内膜癌的放射治疗实践。
制定了一项调查问卷并分发给GCIG成员。GCIG是一个参与妇科肿瘤研究和治疗的全球合作组协会。
从13个不同的合作组共返回34份调查问卷。对于子宫切除术后子宫内膜癌的治疗，盆腔平均（标准差）剂量为47.37（2.32）Gy。盆腔野上界在L4/5水平的有14名受访者，在L5/S1水平的有13名受访者，6份调查问卷未明确说明。当阴道近距离放疗（VBT）与外照射放疗联合使用时，大多数组使用高剂量率（24名受访者），而使用低剂量率的有5名受访者。34名受访者中有28名进行了计算机断层扫描模拟。34名受访者中有3名常规使用调强放疗。对于腹主动脉旁野，上界最常见于T12-L1间隙（28名受访者中有17名），平均（标准差）剂量为46.15（2.18）Gy。对于子宫切除术后单纯VBT，23个组采用高剂量率近距离放疗（平均4.3次插植，剂量为27.57 [10.1 [13] Gy），5个组采用低剂量率近距离放疗（41.45 [17.5] Gy）。28名受访者中有19名在进行VBT时测量了膀胱和直肠的剂量。对于近距离放疗，在阴道治疗范围、所用剂量和方案方面没有统一标准。
GCIG成员组之间的放射治疗实践在外照射剂量和分次剂量方面相似。子宫切除术后近距离放疗实践存在一定差异。在使用外照射的情况下，GCIG成员之间参与放射肿瘤学实践没有严重障碍。
