Zhang Li-xin, Bai Yan-ping, Song Pei-hua, You Li-ping, Yang Ding-quan
Department of Dermatology, China-Japan Friendship Hospital, Beijing, 100029, China.
Chin J Integr Med. 2009 Apr;15(2):141-4. doi: 10.1007/s11655-009-0145-5. Epub 2009 Apr 29.
To observe the clinical curative effect of Chinese herbal medicine combined with acitretin capsule in treating psoriasis of blood-heat syndrome (P-BH).
Eighty patients of P-BH were randomly assigned to two groups, 39 in Group A and 41 in Group B. Both was treated with Chinese herbal medicines for clearing heat, cooling blood and removing toxic substance, and acitretin capsule was given to Group A additionally, with 8 weeks as one therapeutic course. The clinical curative effect was compared between groups, and the change of psoriasis activity severe index (PASI) scores before and after treatment was observed.
The total effective rate in Group A was 84.2% and that in Group B 68.2%, also showing significance between groups (P<0.01). PASI score lowered significantly after treatment in both groups, showing statistical significance (P<0.01), but no significant difference between groups. Little adverse reaction was found in Group B, while in Group A, the adverse reaction was of even milder degree, which could be alleviated by adjusting the herbal medicine and symptomatic treatment administration.
The effect of Chinese herbal medicine combined with acitretin capsule was superior to Chinese herbal medicine alone in treating P-BH, but the adverse reaction of acitretin capsule could be alleviated by adjusting the herbs used. However, the result is waiting to be verified further by larger samples.
观察中药联合阿维A胶囊治疗血热型银屑病（P-BH）的临床疗效。
将80例P-BH患者随机分为两组，A组39例，B组41例。两组均给予清热凉血解毒中药治疗，A组加用阿维A胶囊，以8周为1个疗程。比较两组临床疗效，观察治疗前后银屑病皮损面积和严重程度指数（PASI）评分变化。
A组总有效率为84.2%，B组为68.2%，两组比较差异有统计学意义（P<0.01）。两组治疗后PASI评分均显著降低，差异有统计学意义（P<0.01），但组间比较差异无统计学意义。B组不良反应少，A组不良反应程度更轻，通过调整中药及对症处理可缓解。
中药联合阿维A胶囊治疗P-BH疗效优于单纯中药，但通过调整用药可减轻阿维A胶囊的不良反应。不过，该结果有待更大样本进一步验证。
