Ansari Ramin, Mehrabadi Mahkameh Moradi, Hosseini Mahnaz Sadat, Ghahartars Mehdi, Zarshenas Mohammad Mehdi
Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Curr Drug Discov Technol. 2025;22(4):e15701638327441. doi: 10.2174/0115701638327441241016014503.
Psoriasis is a prevalent inflammatory disease affecting almost 0.5-5% of the world population. Multiple treatment approaches have been developed to manage psoriasis so far. Although concerns exist in the long-term usage of conventional and biological agents in terms of safety, effectiveness, expensiveness, and tolerability, complementary and alternative medicine (CAM) is a promising point of view for future psoriasis management. In this study, databases including Scopus, PubMed, Google Scholar, and Web of Science were searched for relevant literature on herbal medications clinically evaluated for psoriasis, especially those originating from traditional medicine. About 40 relevant papers were selected by March 2023. Most of the studies were clinical trials on poly-herbal formulations from traditional Chinese medicine (TCM). There are controversial results regarding the efficacy of these herbal formulations in psoriasis mainly due to the variation in the study design. Moreover, the probable protective mechanisms and responsible herbal metabolites of these formulations are summarized. There is a global need for more in-vitro and in-vivo studies based on the standard protocols in terms of the evaluation of the safety and efficacy of topical/ systemic herbal preparations for psoriasis.
银屑病是一种常见的炎症性疾病，影响着全球近0.5%-5%的人口。到目前为止，已经开发出多种治疗方法来管理银屑病。尽管传统药物和生物制剂在长期使用方面存在安全性、有效性、昂贵性和耐受性方面的问题，但补充和替代医学（CAM）是未来银屑病管理的一个有前景的观点。在本研究中，检索了包括Scopus、PubMed、谷歌学术和科学网在内的数据库，以查找有关临床上评估用于银屑病的草药药物的相关文献，特别是那些源自传统医学的文献。截至2023年3月，约筛选出40篇相关论文。大多数研究是关于中药复方草药制剂的临床试验。这些草药制剂在银屑病中的疗效存在争议，主要是由于研究设计的差异。此外，总结了这些制剂可能的保护机制和相关的草药代谢产物。在评估局部/全身草药制剂治疗银屑病的安全性和有效性方面，全球需要更多基于标准方案的体外和体内研究。
