落新妇中的三萜类化合物。

Triterpenes from Astilbe chinensis.

作者信息

Hu Jun-Yi, Yao Zhi, Xu Ying-Qian, Takaishi Yoshihisa, Duan Hong-Quan

机构信息

School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.

出版信息

J Asian Nat Prod Res. 2009;11(3):236-42. doi: 10.1080/10286020802682866.

DOI:10.1080/10286020802682866

PMID:19408147

Abstract

Six new triterpenes, 3beta,6beta-dihydroxyurs-12-en-27-oic acid (1), 3beta,6beta,24-trihydroxyurs-12-en-27-oic acid (2), 3beta,6beta,7alpha-trihydroxyurs-12-en-27-oic acid (3), 3beta-acetoxy-6beta-hydroxyurs-12-en-27-oic acid (4), 3beta,6beta,24-trihydroxyolean-12-en-27-oic acid (5), and 3beta,6beta,7alpha-trihydroxyolean-12-en-27-oic acid (6), were isolated from the rhizomes of Astilbe chinensis. Their structures were elucidated on the basis of 1D- and 2D-NMR analyses and HR-MS experiments. The isolated compounds exhibited significant cytotoxic activities against the SK-N-SH and HL-60 cell lines.

摘要

从中华落新妇的根茎中分离出6种新的三萜类化合物，分别为3β,6β - 二羟基乌苏 - 12 - 烯 - 27 - 酸（1）、3β,6β,24 - 三羟基乌苏 - 12 - 烯 - 27 - 酸（2）、3β,6β,7α - 三羟基乌苏 - 12 - 烯 - 27 - 酸（3）、3β - 乙酰氧基 - 6β - 羟基乌苏 - 12 - 烯 - 27 - 酸（4）、3β,6β,24 - 三羟基齐墩果 - 12 - 烯 - 27 - 酸（5）和3β,6β,7α - 三羟基齐墩果 - 12 - 烯 - 27 - 酸（6）。通过一维和二维核磁共振分析以及高分辨质谱实验对它们的结构进行了阐明。分离得到的化合物对SK - N - SH和HL - 60细胞系表现出显著的细胞毒活性。