一种用于监测主要组织相容性复合体-肽相互作用的氙-129生物传感器。
A xenon-129 biosensor for monitoring MHC-peptide interactions.
作者信息
Schlundt Andreas, Kilian Wolfgang, Beyermann Michael, Sticht Jana, Günther Sebastian, Höpner Sabine, Falk Kirsten, Roetzschke Olaf, Mitschang Lorenz, Freund Christian
机构信息
Protein Engineering Group, Leibniz-Institut für Molekulare Pharmakologie und FU Berlin, Robert-Roessle-Strasse 10, 13125 Berlin, Germany.
出版信息
Angew Chem Int Ed Engl. 2009;48(23):4142-5. doi: 10.1002/anie.200806149.
Caged in: The formation of a complex between a peptide ligand and a major histocompatibility complex (MHC) class II protein is detected by a (129)Xe biosensor. Cryptophane molecules that trap Xe atoms are modified with a hemagglutinin (HA) peptide, which binds to the MHC protein. The interaction can be monitored by an NMR chemical shift change of cage-HA bound (129)Xe.
受限状态
通过（129）Xe生物传感器检测肽配体与主要组织相容性复合体（MHC）II类蛋白之间复合物的形成。捕获Xe原子的穴状化合物分子用与MHC蛋白结合的血凝素（HA）肽进行修饰。这种相互作用可以通过笼状-HA结合的（129）Xe的核磁共振化学位移变化来监测。
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