早期舌癌N0颈部选择性颈清扫术与观察的前瞻性随机研究。
Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma.
作者信息
Yuen Anthony Po-Wing, Ho Chiu Ming, Chow Tam Lin, Tang Lap Chiu, Cheung Wing Yung, Ng Raymond Wai-Man, Wei William Ignace, Kong Chi Kwan, Book Kwok Shing, Yuen Wai Cheung, Lam Alfred King-Yin, Yuen Nancy Wah-Fun, Trendell-Smith Nigel Jeremy, Chan Yue Wai, Wong Birgitta Yee-Hang, Li George Kam-Hop, Ho Ambrose Chung-Wai, Ho Wai Kuen, Wong Sau Yan, Yao Tzy-Jyun
机构信息
Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong.
出版信息
Head Neck. 2009 Jun;31(6):765-72. doi: 10.1002/hed.21033.
BACKGROUND
There are controversies on the benefits of elective neck dissection (END) for oral tongue carcinoma.
METHOD
This is a prospective randomized study of elective selective I, II, III neck dissection versus observation for N0 neck of stage I to II oral tongue carcinoma. There were 35 patients on the observation arm and 36 patients on the END arm. The main outcome assessment parameters are node-related mortality and disease-specific survival rate.
RESULTS
There were 11 patients in the observed arm and 2 patients in the END arm who developed nodal recurrence alone without associated local or distant recurrence. All 13 patients were salvaged, and no patient died of nodal recurrence. The 5-year disease-specific survival rate was 87% for the observation arm and was 89% for the END arm; the 2% difference was not significant.
CONCLUSION
Observation may be an acceptable alternative to END if strict adherence to a cancer surveillance protocol is followed.
背景
对于口腔舌癌患者，选择性颈清扫术（END）的益处存在争议。
方法
这是一项前瞻性随机研究，比较选择性Ⅰ、Ⅱ、Ⅲ区颈清扫术与对Ⅰ至Ⅱ期口腔舌癌N0颈部进行观察的效果。观察组有35例患者，END组有36例患者。主要结局评估参数为淋巴结相关死亡率和疾病特异性生存率。
结果
观察组有11例患者、END组有2例患者单独出现淋巴结复发，无相关局部或远处复发。所有13例患者均成功救治，无患者死于淋巴结复发。观察组5年疾病特异性生存率为87%，END组为89%；2%的差异无统计学意义。
结论
如果严格遵循癌症监测方案，观察可能是END的一种可接受的替代方案。
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