Ech-Charif S, Benhammou A, Maher M, Séfiani S
CHU, Hôpital des Spécialités, Service d'Anatomie pathologique, Rabat, Maroc.
Rev Laryngol Otol Rhinol (Bord). 2008;129(4-5):337-40.
Infantile myofibromatosis (IMF) are integrated in the group of fibromatosis juvenile-type which are benign mesenchymal lesions, characterized morphologically by a proliferation of fibroblasts and myofibroblastes, with perivascular pattern. Through a case of solitary myofibroma of the mandible, we will emphasize anatomo-clinical features and differential diagnosis.
We report a case illustrating solitary myofibroma of the mandible in 18 month old infant.
The histological diagnosis was done on the identification of two separate components, a fascicular myofibroblastic pattern at the periphery with a hemangiopericytoma like pattern in the centre. Both components positive for alpha-smooth muscle actin and vimentin.
Solitary IMF is characterised by a single lesion arising from cutaneous, bony or soft tissues. Morphological and immunohistochemical examination allow the diagnosis of the typical form. The differential diagnosis includes other benign spindle cells tumours. The prognosis is excellent with possibility to regress spontaneously.
婴儿肌纤维瘤病（IMF）属于青少年型纤维瘤病组，是良性间叶性病变，其形态学特征为成纤维细胞和肌成纤维细胞增生，呈血管周围模式。通过1例下颌骨孤立性肌纤维瘤病例，我们将强调其解剖临床特征及鉴别诊断。
我们报告1例18个月大婴儿下颌骨孤立性肌纤维瘤病例。
组织学诊断基于识别两个不同成分，外周为束状肌成纤维细胞模式，中央为血管外皮细胞瘤样模式。两种成分α-平滑肌肌动蛋白和波形蛋白均呈阳性。
孤立性IMF的特征是单个病变，起源于皮肤、骨骼或软组织。形态学和免疫组化检查有助于典型病例的诊断。鉴别诊断包括其他良性梭形细胞肿瘤。预后极佳，有可能自发消退。
