Grabarević Zeljko, Spoljar Jadranka Bubić, Kurilj Andrea Gudan, Sostarić-Zuckermann Ivan-Conrado, Artuković Branka, Hohsteter Marko, Beck Ana, Dzaja Petar, Strmecki Nadica Maltar
Department of General Pathology and Pathological Morphology, Veterinary Faculty Zagreb, University of Zagreb, Croatia.
Coll Antropol. 2009 Mar;33(1):253-8.
Incidence of mast cell tumors, their distribution according to sex, breed, age and localisation in Croatia is not established yet. Also, the statistical significance of the various histopathological parameters according to Patnaik's scheme, in the diagnostics of the tumor grade was not performed. Investigation analysed mast cell tumors histopathologicaly characterized at the Department of General Pathology and Pathological Morphology of the Veterinary Faculty Zagreb from January 1st 2002 to December 31st 2006. Sex, age, breed, localisation and tumor grade of each animal with tumor was recorded and statisticaly evaluated. Each histopathological variable was scored and compared with tumor grade. In the analyzed period, totally 1630 tumors were recorded, and mast cell tumors were found in 106 animals or in 6.5% of all cases. With statistically significant difference, this tumor was found in more cases in male dogs, and average age was 6.96 years. Boxers and retrievers were most frequent breeds, and localization was mostly on legs. Grade I tumor was found in 15.09%, grade II in 44.34% and grade III in 28.3% of animals. There were no significant correlations between tumor grade and age, breed, sex or localization. Considering the lesion scores compared with grade, statistically significant differences were found in cell shape, number of nucleoli, anisocytosis, anisokariosis, karyomegaly, mitoses, necroses, hemorrhages, cellularity, cell borders and collagenolysis.
克罗地亚肥大细胞瘤的发病率、按性别、品种、年龄和部位的分布情况尚未确定。此外，根据帕特奈克（Patnaik）方案，各种组织病理学参数在肿瘤分级诊断中的统计学意义也未进行研究。本调查对2002年1月1日至2006年12月31日在萨格勒布兽医学院普通病理学和病理形态学系进行组织病理学特征分析的肥大细胞瘤进行了研究。记录了每只患有肿瘤动物的性别、年龄、品种、部位和肿瘤分级，并进行了统计学评估。对每个组织病理学变量进行评分，并与肿瘤分级进行比较。在分析期间，共记录了1630个肿瘤，在106只动物中发现了肥大细胞瘤，占所有病例的6.5%。在雄性犬中发现该肿瘤的病例更多，差异具有统计学意义，平均年龄为6.96岁。拳师犬和寻回犬是最常见的品种，肿瘤大多位于腿部。I级肿瘤在15.09%的动物中发现，II级在44.34%的动物中发现，III级在28.3%的动物中发现。肿瘤分级与年龄、品种、性别或部位之间无显著相关性。考虑到与分级相比的病变评分，在细胞形状、核仁数量、细胞大小不均、核大小不均、核肿大、有丝分裂、坏死、出血、细胞密度、细胞边界和胶原溶解方面发现了统计学上的显著差异。
