Śmiech Anna, Ślaska B, Łopuszyński W, Jasik A, Szczepanik M, Wilkołek P
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Pol J Vet Sci. 2017 Sep 26;20(3):455-465. doi: 10.1515/pjvs-2017-0055.
The aim of the study was to identify significant relationships between the tumour malignancy grade and dogs' age, breed, sex, size, and location of mast cell tumours (MCTs). MCTs accounted for 13.27% of all diagnosed canine skin tumours. The highest incidence was recorded among Boxers, Labrador Retrievers, American Staffordshire Terriers, and Golden Retrievers. Statistical analysis revealed significantly higher probability of occurrence of the grade I mast cell tumour in the French Bulldog in the head, neck, torso, and limb regions, the grade-II mast cell tumour in Boxer, Doberman, Dachshund, shepherds, and setters in the scrotal region, and the grade III mast cell tumour in Shar-Pei in the axilla region. In the group of the oldest dogs aged 11-16, there was higher risk of development of MCTs grade II and III. Young dogs (aged 2-3 and 4-6) were found to be more prone to development of MCTs grade I. There was no correlation between MCTs grade and dogs' sex and size. To the authors' knowledge this is the first report on statistical relationships between the degree of mast cell tumour malignancy and dogs' phenotypic traits, age and tumour location. This analysis indicate predilections for development of the particular mast cell tumour malignancy degrees in certain dog breeds, age, and anatomical location.
该研究的目的是确定肿瘤恶性程度与犬的年龄、品种、性别、体型以及肥大细胞瘤（MCT）的位置之间的显著关系。MCT占所有已诊断犬皮肤肿瘤的13.27%。发病率最高的是拳师犬、拉布拉多寻回犬、美国斯塔福郡梗犬和金毛寻回犬。统计分析显示，法国斗牛犬头部、颈部、躯干和四肢区域发生I级肥大细胞瘤的概率显著更高，拳师犬、杜宾犬、腊肠犬、牧羊犬和塞特犬阴囊区域发生II级肥大细胞瘤的概率显著更高，沙皮犬腋窝区域发生III级肥大细胞瘤的概率显著更高。在11至16岁的老龄犬组中，发生II级和III级MCT的风险更高。发现幼犬（2至3岁和4至6岁）更容易发生I级MCT。MCT分级与犬的性别和体型之间没有相关性。据作者所知，这是关于肥大细胞瘤恶性程度与犬的表型特征、年龄和肿瘤位置之间统计关系的首份报告。该分析表明特定犬种、年龄和解剖位置对特定肥大细胞瘤恶性程度的发生具有偏好性。
