Giunta Brian, Somboonwit Charurut, Nikolic William V, Rrapo Elona, Tan Jun, Shapshak Paul, Fernandez Francisco
Department of Psychiatry, Institute for Research in Psychiatry Neuroimmunology Laboratory, University of South Florida College of Medicine, Tampa, FL 33613, USA.
Crit Rev Neurobiol. 2007;19(2-3):79-118. doi: 10.1615/critrevneurobiol.v19.i2-3.20.
Hepatitis-C virus (HCV) has infected an estimated 130 million people worldwide, most of whom are chronically infected. Infection is marked by both treatment- and non-treatment-related psychiatric symptoms. Symptoms associated with antiretroviral therapy, interferon-alpha (IFN-alpha), include acute confusional states, delirium, depression, irritability, and even mania. These psychiatric symptoms are further complicated by the high rate of substance abuse and comorbid HIV infection inherent to this population. Even in the absence of IFN-alpha therapy, comorbid depression, cognitive decline, and especially fatigue are common in patients suffering HCV. These comorbidities have significant effects on both treatments and outcomes, and thus are reviewed herein.
丙型肝炎病毒（HCV）估计已感染全球1.3亿人，其中大多数为慢性感染。感染的特征是出现与治疗相关和与非治疗相关的精神症状。与抗逆转录病毒疗法、α干扰素（IFN-α）相关的症状包括急性意识错乱状态、谵妄、抑郁、易怒，甚至躁狂。该人群中固有的药物滥用高发生率和合并HIV感染使这些精神症状更加复杂。即使在没有IFN-α治疗的情况下，合并抑郁症、认知能力下降，尤其是疲劳在丙型肝炎患者中也很常见。这些合并症对治疗和预后都有显著影响，因此本文将对其进行综述。
