Federal University of Bahia, Institute of Health Sciences, Postgraduate Program in Interactive Processes of Organs and Systems, Salvador, BA, Brazil; Nova Esperança Medical School, João Pessoa, PB, Brazil; Hospital Complex of Infectious Diseases Clementino Fraga, João Pessoa, PB, Brazil.
Federal University of Bahia, Postgraduate Program in Medicine and Health, Salvador, BA, Brazil; Federal University of Bahia, Psychiatry Service, University Hospital (Com-HUPES), Salvador, BA, Brazil.
Braz J Infect Dis. 2019 Jul-Aug;23(4):224-230. doi: 10.1016/j.bjid.2019.06.013. Epub 2019 Jul 22.
Human T-cell lymphotropic virus type 1 (HTLV-1) has low prevalence rates, but is endemic in some regions of the world. It is usually a chronic asymptomatic infection, but it can be associated with serious neurologic and urinary conditions. Hepatitis C virus (HCV) is broadly spread out worldwide. The majority of these infections have a chronic course that may progress to cirrhosis and hepatocellular carcinoma.
To compare sociodemographic and mental health (risk behaviors, depression, and suicide) aspects, and quality of life among patients with HCV or HTLV-1.
Observational, comparative and cross-sectional study involving outpatients with HCV or HLTV-1 infection. Sociodemographic characteristics, risk behaviors and quality of life were assessed through the questionnaires Mini International Neuropsychiatric Interview - MINI Plus (depression and suicide) and Medical Outcomes Study 36-Item Short-Form Health Survey (quality of life). Univariate and multivariate statistical analyses (hierarchical logistic regression) were conducted.
143 individuals with HCV and 113 individuals with HTLV-1 infection were included. Males were predominant in the HCV group (68.8%) and females in the HTLV-1 group (71.7%). The frequency of risk behaviors (sexual and drug use) was greater in those with HCV (p < 0.05). A past depressive episode was more common in the HTLV-1 group (p = 0.037). Quality of life was significantly worse in the physical functioning, vitality, mental health, and social functioning domains in those with HTLV-1 (p < 0.05). HTLV-1 infection remained independently associated with worse quality of life in multivariate analysis.
Risk behaviors are frequent among those infected with HCV. Additionally, despite HTLV-1 being considered an infection with low morbidity, issues related to mental health (depressive episode) and decreased quality of life are relevant.
比较丙型肝炎病毒（HCV）或人类 T 细胞嗜淋巴细胞病毒 1 型（HTLV-1）患者的社会人口统计学和心理健康（风险行为、抑郁和自杀）以及生活质量方面。
这是一项观察性、比较性和横断面研究，纳入了 HCV 或 HTLV-1 感染的门诊患者。通过 Mini International Neuropsychiatric Interview - MINI Plus（抑郁和自杀）和 Medical Outcomes Study 36-Item Short-Form Health Survey（生活质量）评估社会人口统计学特征、风险行为和生活质量。进行了单变量和多变量统计分析（分层逻辑回归）。
纳入了 143 名 HCV 患者和 113 名 HTLV-1 感染患者。男性在 HCV 组中占主导地位（68.8%），而女性在 HTLV-1 组中占主导地位（71.7%）。HCV 组的风险行为（性行为和药物使用）频率更高（p<0.05）。HTLV-1 组过去有抑郁发作的频率更高（p=0.037）。在 HTLV-1 组中，生理功能、活力、心理健康和社会功能领域的生活质量明显更差（p<0.05）。在多变量分析中，HTLV-1 感染与较差的生活质量仍然独立相关。
HCV 感染者中风险行为较为常见。此外，尽管 HTLV-1 被认为是一种发病率较低的感染，但与心理健康（抑郁发作）和生活质量下降相关的问题仍然值得关注。
