Puyal Julien, Ginet Vanessa, Vaslin Anne, Truttmann Anita C, Clarke Peter G H
Département de Biologie Cellulaire et de Morphologie (DBCM), Université de Lausanne, CH-1005 Lausanne, Suisse.
Med Sci (Paris). 2009 Apr;25(4):383-90. doi: 10.1051/medsci/2009254383.
Autophagy is a cellular mechanism for degrading proteins and organelles. It was first described as a physiological process essential for maintaining homeostasis and cell survival, but understanding its role in conditions of stress has been complicated by the recognition of a new type of cell death ("type 2") characterized by deleterious autophagic activity. This paradox is important in the central nervous system where the activation of autophagy seems to be protective in certain neurodegenerative diseases but deleterious in cerebral ischemia. The development of new therapeutic strategies based on the manipulation of autophagy will need to take into account these opposing roles of autophagy.
自噬是一种降解蛋白质和细胞器的细胞机制。它最初被描述为维持体内平衡和细胞存活所必需的生理过程，但随着一种以有害自噬活性为特征的新型细胞死亡（“2型”）的发现，了解其在应激条件下的作用变得复杂起来。这种矛盾在中枢神经系统中很重要，在某些神经退行性疾病中，自噬的激活似乎具有保护作用，但在脑缺血中却是有害的。基于自噬调控的新治疗策略的开发需要考虑到自噬的这些相反作用。
