Coustau Christine
U547 Inserm Schistosomiase, paludisme et inflammation, Institut Pasteur de Lille, 59019 Lille Cedex, France.
Med Sci (Paris). 2009 Apr;25(4):399-403. doi: 10.1051/medsci/2009254399.
Aquatic snails play a key role in the transmission of parasites such as the human blood or liver flukes (Schistosomes and Fasciola sp.). During the last decade, particular efforts have been made by a small number of scientists to progress in our understanding of the molecular mechanisms underlying snail immune responses and/or host parasite interactions. Complementary approaches using the gastropod snail Biomphalaria glabrata, an intermediate host of Schistosoma mansoni, have yielded a number of unexpected results such as the existence of highly diversified pathogen-binding proteins (FREPs), or potential immune regulators similar to mammalian cytokines. Although molecular immune processes largely remain to be elucidated, accumulating data support the idea that snail innate immunity is much more complex than originally thought.
水生蜗牛在诸如人类血液吸虫或肝吸虫（血吸虫和片形吸虫属）等寄生虫的传播中起着关键作用。在过去十年中，少数科学家做出了特别努力，以增进我们对蜗牛免疫反应和/或宿主-寄生虫相互作用背后分子机制的理解。使用曼氏血吸虫的中间宿主——腹足纲蜗牛光滑双脐螺的互补方法，已经产生了许多意想不到的结果，例如存在高度多样化的病原体结合蛋白（FREPs），或类似于哺乳动物细胞因子的潜在免疫调节因子。尽管分子免疫过程在很大程度上仍有待阐明，但越来越多的数据支持这样一种观点，即蜗牛的先天免疫比最初认为的要复杂得多。
