在最近测序的[物种名称]基因组中含硫酯相关蛋白的比较功能研究
Comparative Functional Study of Thioester-containing Related Proteins in the Recently Sequenced Genome of .
作者信息
Falade Mofolusho O, Otarigho Benson
机构信息
Cellular Parasitology Programme, Cell Biology and Genetics Unit, Department of Zoology, University of Ibadan, Ibadan, Nigeria.
Dept. of Biological Science, Edo University, Iyamho, Edo State, Nigeria.
出版信息
Iran J Parasitol. 2018 Jan-Mar;13(1):79-88.
BACKGROUND
There is paucity of information on functional relationship and characterization of thioester-containing proteins (TEP) to other well-annotated homologues. We performed functional characterization studies of TEP to homologues in and in disparate invertebrates.
METHODS
Genomic sequences of TEPs were retrieved after annotation of the genome. In addition, TEP sequences deposited in NCBI protein database were also retrieved and utilized for sequence analysis. TEP relatedness to its other homologues as well as functional domain and protein-protein interaction analysis was performed.
RESULTS
Our analysis resulted in the identification of TEPs in a number of organisms including, , , and In addition, we identified 19 TEP sequences spread across 10 animal species The genome contains 14190 unannotated proteins after filtration with about 85% of its proteome annotated. The phylogenetics, functional domain and protein-protein interaction analyses suggest an immunological role for TEP in .
CONCLUSION
The predicted role of thioester-containing proteins to be involved in immunological role in may have a strong effect on resistance to infection.
背景
关于含硫酯蛋白（TEP）与其他注释完善的同源物之间的功能关系和特征的信息匮乏。我们对TEP在[具体生物名称1]和不同无脊椎动物中的同源物进行了功能特征研究。
方法
在注释[具体生物名称2]基因组后检索TEP的基因组序列。此外，还检索了NCBI蛋白质数据库中存储的TEP序列并用于序列分析。进行了TEP与其其他同源物的相关性以及功能域和蛋白质-蛋白质相互作用分析。
结果
我们的分析在包括[具体生物名称1]、[具体生物名称2]、[具体生物名称3]和[具体生物名称4]等多种生物中鉴定出了TEP。此外，我们在10个动物物种中鉴定出19个TEP序列。[具体生物名称2]基因组在过滤后包含14190个未注释的蛋白质，其蛋白质组约85%已注释。系统发育、功能域和蛋白质-蛋白质相互作用分析表明TEP在[具体生物名称2]中具有免疫作用。
结论
预测含硫酯蛋白在[具体生物名称2]中参与免疫作用可能对抵抗感染有很大影响。
Zotero 插件