Aguilera Peiró P, Vicente Villa A, González Enseñat M A, Ros Viladoms J, Antón López J, Velasco Sánchez D
Sección de Dermatología, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.
An Pediatr (Barc). 2009 Mar;70(3):287-92. doi: 10.1016/j.anpedi.2008.10.019. Epub 2009 Feb 8.
Neonatal lupus erythematosus (NLE) is an uncommon disease described mainly through isolated case reports and a few published series.
To examine the clinical and serological spectrum, and course of the disease in neonates with NLE and cutaneous involvement.
A retrospective study was performed that included all children with NLE that came to the Dermatology Department between 1995 and 2006.
Eight children with a diagnosis of NLE with cutaneous involvement were identified, with a male:female ratio of 3:1. Anti-Ro antibodies were found in all cases and no cases with anti-RNP antibodies were found. Facial lesions were observed in all cases and in 7 cases the skin eruptions cleared within 4.3 months; the remaining patient was still in follow up when the data were collected. The clinical course of patients who were followed up was satisfactory.
In our series, NLE was three times more frequent in males. Involvement of sun-exposed areas, such as the face with annular lesions was the most common finding. We found one case of NLE with cutaneous involvement and persistent ductus arteriosus. Anti-Ro antibodies were found in all cases and skin eruptions cleared by 7 months of age, concurrent with the waning of the maternally derived antibodies. Four of the mothers were asymptomatic and unaware of their condition, emphasizing the importance of following up these patients due to the possibility of developing an autoimmune disease.
新生儿红斑狼疮（NLE）是一种罕见疾病，主要通过个别病例报告和少数已发表的系列研究进行描述。
研究患有NLE且有皮肤受累的新生儿的临床和血清学特征以及疾病进程。
进行了一项回顾性研究，纳入了1995年至2006年间到皮肤科就诊的所有NLE患儿。
确定了8例诊断为NLE且有皮肤受累的患儿，男女比例为3:1。所有病例均检测到抗Ro抗体，未发现抗RNP抗体阳性病例。所有病例均有面部皮损，7例患儿的皮疹在4.3个月内消退；在收集数据时，其余1例患儿仍在随访中。接受随访的患儿临床病程良好。
在我们的系列研究中，NLE在男性中的发病率是女性的三倍。暴露于阳光下的部位受累，如面部出现环形皮损是最常见的表现。我们发现1例NLE患儿有皮肤受累且伴有动脉导管未闭。所有病例均检测到抗Ro抗体，皮疹在7个月龄时消退，同时母体来源的抗体减少。4名母亲无症状且未意识到自身病情，强调了对这些患者进行随访的重要性，因为她们有可能发展为自身免疫性疾病。
