Vázquez-Botet M, Rodríguez R, Sánchez J L
Department of Dermatology, University of Puerto Rico, School of Medicine, San Juan 00936-5067.
P R Health Sci J. 1997 Jun;16(2):162-6.
This is a case of an infant with neonatal lupus erythematosus who presented the characteristic cutaneous lesions without evidence of systemic involvement. NLE is a rare condition which affects newborn infants from mothers who may me asymptomatic or have a connective tissue disease, with or without autoantibodies to extractable nuclear antigens Ro (SS-A), LA (SS-B) or ribonucleoproteins. The skin lesions are usually annular in configuration and resemble those of subacute cutaneous lupus erythematosus. Congenital complete heart block (CHB) may be present in addition to the cutaneous lesions. This is a review of NLE focusing on its clinical manifestations, serologic markers, pathogenesis and treatment.
这是一例新生儿红斑狼疮患儿，其出现了特征性皮肤损害，但无全身受累证据。新生儿红斑狼疮是一种罕见疾病，可影响来自无症状或患有结缔组织病母亲的新生儿，母亲可有或无针对可提取核抗原Ro（SS - A）、La（SS - B）或核糖核蛋白的自身抗体。皮肤损害通常呈环状，类似于亚急性皮肤型红斑狼疮。除皮肤损害外，还可能存在先天性完全性心脏传导阻滞。本文是对新生儿红斑狼疮的综述，重点关注其临床表现、血清学标志物、发病机制及治疗。
