Durieu I, Parent M, Ajana F, Gosset P, Smadja D, Leclerc X, Fournier Y, Leys D
Department of Neurology, Hôpital B, Lille, France.
J Neurol Neurosurg Psychiatry. 1991 Aug;54(8):731-3. doi: 10.1136/jnnp.54.8.731.
Twenty nine cases of central nervous system infection due to Monosporium apiospermum have been reported. Six of them occurred after an aspiration pneumonia following a near drowning. The case of a 53 year old man is reported: M apiospermum was isolated from cerebrospinal fluid, sputum, urine and from the mud of the ditch where the patient had fallen. Though the treatment used recommended doses of intravenous, intrathecal and intraventricular amphotericin B, it was ineffective and the patient died 97 days after the near drowning. Necropsy showed that the ventricular infectious process was more prominent distant from the antifungal ventricular source.
已报告29例由阿氏支孢霉引起的中枢神经系统感染。其中6例发生在近乎溺亡后继发的吸入性肺炎之后。报告了一名53岁男性的病例：从脑脊液、痰液、尿液以及患者坠落后所在沟渠的泥浆中分离出了阿氏支孢霉。尽管采用了推荐剂量的静脉注射、鞘内注射和脑室内注射两性霉素B进行治疗，但无效，患者在近乎溺亡97天后死亡。尸检显示，脑室感染过程在远离抗真菌脑室源处更为突出。
