溺水后由尖端赛多孢子菌感染引起的多器官受累：一例报告及文献复习
Multi-organ involvement caused by Scedosporium apiospermum infection after near drowning: a case report and literature review.
作者信息
Yao Yao, Xu Qian, Liang Wenwen, Ji Suqiong, Kosari Mohammadreza, Xu Shabei, Zhu Zhou, Mao Zhijuan
机构信息
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
出版信息
BMC Neurol. 2024 Apr 15;24(1):124. doi: 10.1186/s12883-024-03637-9.
BACKGROUND
Scedosporium apiospermum (S. apiospermum) is a rare fungal pathogen that causes disseminated infections. It rarely affects immunocompetent individuals and has a poor prognosis.
CASE PRESENTATION
A 37-year-old woman presented with multiple lesions in the lungs, brain, and eyes, shortly after near drowning in a car accident. The primary symptoms were chest tightness, limb weakness, headache, and poor vision in the left eye. S. apiospermum infection was confirmed by metagenomic next-generation sequencing (mNGS) of intracranial abscess drainage fluid, although intracranial metastases were initially considered. After systemic treatment with voriconazole, her symptoms improved significantly; however, she lost vision in her left eye due to delayed diagnosis.
CONCLUSION
While S. apiospermum infection is rare, it should be considered even in immunocompetent patients. Prompt diagnosis and treatment are essential. Voriconazole may be an effective treatment option.
背景
伪阿利什霉是一种可引发播散性感染的罕见真菌病原体。它很少感染免疫功能正常的个体，且预后较差。
病例报告
一名37岁女性在车祸中险些溺水后不久，出现肺部、脑部和眼部的多处病变。主要症状为胸闷、肢体无力、头痛以及左眼视力下降。尽管最初考虑为颅内转移瘤，但通过对颅内脓肿引流液进行宏基因组二代测序（mNGS）确诊为伪阿利什霉感染。经伏立康唑全身治疗后，她的症状显著改善；然而，由于诊断延误，她左眼失明。
结论
虽然伪阿利什霉感染罕见，但即使在免疫功能正常的患者中也应予以考虑。及时诊断和治疗至关重要。伏立康唑可能是一种有效的治疗选择。
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