Levin H S
Division of Neurosurgery, University of Texas Medical Branch, Galveston.
J Neurol Sci. 1991 Jul;103 Suppl:S39-42. doi: 10.1016/0022-510x(91)90007-t.
To evaluate the efficacy of cytidine diphosphoryl choline (CDP-choline) in treating postconcussional symptoms for one month after mild to moderate closed head injury (CHI), we completed a preliminary double blind placebo-controlled study. Fourteen young men admitted to the neurosurgery service after sustaining mild to moderate CHI were randomized to oral CDP-choline (1 g) and placebo control groups which were matched for age, education and severity of impaired consciousness. Baseline (prior to discharge) and one month examinations consisted of a structured postconcussional symptom interview and neuropsychological tests. Results (Wilcoxon test) showed that CDP-choline produced a greater reduction of postconcussional symptoms than placebo (P less than 0.005). Analysis of the neuropsychological findings revealed a significantly greater improvement in recognition memory for designs in the CDP-choline treated patients (P less than 0.02) whereas other changes in test performance did not differ for the two groups. Pending replication in a larger series of patients, our findings suggest that CDP-choline may be effective in treating sequelae of mild to moderate CHI.
为评估胞二磷胆碱（CDP - 胆碱）治疗轻至中度闭合性颅脑损伤（CHI）后一个月脑震荡后症状的疗效，我们完成了一项初步的双盲安慰剂对照研究。14名在遭受轻至中度CHI后入住神经外科的年轻男性被随机分为口服CDP - 胆碱（1克）组和安慰剂对照组，两组在年龄、教育程度和意识障碍严重程度方面相匹配。基线（出院前）和一个月检查包括结构化的脑震荡后症状访谈和神经心理学测试。结果（Wilcoxon检验）显示，CDP - 胆碱比安慰剂能更有效地减轻脑震荡后症状（P小于0.005）。对神经心理学结果的分析显示，接受CDP - 胆碱治疗的患者在图案识别记忆方面有显著更大的改善（P小于0.02），而两组在测试表现的其他变化方面没有差异。在更多患者中重复验证之前，我们的研究结果表明CDP - 胆碱可能对治疗轻至中度CHI的后遗症有效。
