促炎细胞因子刺激对人类乳腺癌的影响：趋化因子受体表达在癌症转移中的意义。
Effect of pro-inflammatory cytokine stimulation on human breast cancer: implications of chemokine receptor expression in cancer metastasis.
作者信息
Valdivia-Silva Julio E, Franco-Barraza Janusz, Silva Ana Luisa Esparza, Pont Gisela Du, Soldevila Gloria, Meza Isaura, García-Zepeda Eduardo A
机构信息
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, Circuito exterior s/n, C.P. 04510 DF, Mexico.
出版信息
Cancer Lett. 2009 Oct 8;283(2):176-85. doi: 10.1016/j.canlet.2009.03.040. Epub 2009 May 5.
Interactions between tumour cells and microenvironments may affect their growth and metastasis formation. In search for a better understanding of the role of cellular mediators in the progression of cancer, we investigated the effect of pro-inflammatory cytokines IL-1, IL-6, TNF-alpha and IFN-gamma on the regulation of expression of chemokine receptors CXCR4, CXCR2, CX3CR1, CCR9, and CCR5 in the human breast cancer cell line MCF-7. Our results showed that IL-1 increased CXCR4 expression whereas TNF-alpha increased CX3CR1, CCR9 and CCR5. Interestingly, this regulation was not homogeneous, emphasizing the inherent heterogeneity in cancer that may be responsive to specific inflammatory microenvironments.
肿瘤细胞与微环境之间的相互作用可能会影响它们的生长和转移形成。为了更好地理解细胞介质在癌症进展中的作用，我们研究了促炎细胞因子白细胞介素-1（IL-1）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和干扰素-γ（IFN-γ）对人乳腺癌细胞系MCF-7中趋化因子受体CXCR4、CXCR2、CX3CR1、CCR9和CCR5表达调控的影响。我们的结果表明，IL-1增加了CXCR4的表达，而TNF-α增加了CX3CR1、CCR9和CCR5的表达。有趣的是，这种调控并不一致，这突出了癌症中可能对特定炎症微环境有反应的内在异质性。
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