Rumbach L, Armspach J P, Gounot D, Namer I J, Chambron J, Warter J M, Collard M
Service d'Explorations Fonctionnelles du Système Nerveux, Centre Hospitalo-Universitaire, Strasbourg, France.
J Neurol Sci. 1991 Aug;104(2):176-81. doi: 10.1016/0022-510x(91)90307-s.
An original method was used to carry out the mathematical analysis of T2 transverse magnetization decay curves and the measure of T2 relaxation times on multiple sclerosis (MS) patients. The presumably normal white matter (WM) of these patients presented higher T2 relaxation times (98.6 msec), in comparison with that found in a population sample (88 msec). In this case, magnetization decay curves remain mostly monoexponential and are characterized by a single T2. On the other hand, areas of increased signal (AIS) curves are always better fitted by a biexponential function characterized by a short (82 msec) and a long (greater than 200 msec) T2. The spreading out of long T2 varies from one AIS to another in the same patient and among different patients; values of long T2 also vary with time, but without any correlation with the clinical state. In fact, no correlation was been established between relaxation times and clinical parameters. Quantitative MRI therefore enables a different approach to interpret MRI images; results suggest that several histobiochemical parameters play a role in the pathogenesis of an AIS and that MS is a dynamic and constantly evolving disease.
采用一种原始方法对多发性硬化症（MS）患者的T2横向磁化衰减曲线进行数学分析，并测量T2弛豫时间。与人群样本（88毫秒）相比，这些患者推测正常的白质（WM）呈现出更高的T2弛豫时间（98.6毫秒）。在这种情况下，磁化衰减曲线大多保持单指数形式，并以单一的T2为特征。另一方面，信号增强区域（AIS）曲线总是能更好地用双指数函数拟合，该双指数函数的特征是短T2（82毫秒）和长T2（大于200毫秒）。在同一患者的不同AIS之间以及不同患者之间，长T2的分布情况各不相同；长T2的值也随时间变化，但与临床状态无任何关联。事实上，弛豫时间与临床参数之间未建立相关性。因此，定量MRI能够提供一种不同的方法来解读MRI图像；结果表明，若干组织生物化学参数在AIS的发病机制中起作用，并且MS是一种动态且不断演变的疾病。
