Department of Pathology, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil.
Pathol Res Pract. 2010 Feb 15;206(2):130-3. doi: 10.1016/j.prp.2009.03.006. Epub 2009 May 2.
Melanocytoma is a rare intraocular tumor. There are some reports in the literature dealing with primary melanocytomas of the choroid and ciliary body. It is believed that most of these tumors are clinically diagnosed as nevi or melanoma, and are followed up or treated without surgical resection, respectively. Some clinical features can give a clue as to the correct diagnosis. We report on a 47-year-old white female with progressive visual loss of 2 months and right painful eye. Her visual acuity of finger counting was confined to 3.0m OD and 20/20 OS. Biomicroscopy OD showed a 360 degrees posterior synechia, and fundoscopy was not conclusive due to vitreous opacity. No alterations were seen on OS. Intraocular pressure was normal, and the pupillary reflex was present in both eyes. An ultrasound of the OD showed an elevated tumor on topography of the ciliary body and anterior choroid at the ora serrata level. Melanoma was the main diagnosis considered, and enucleation was indicated due to poor prognosis for visual acuity. Gross and histopathologic examinations of the OD showed a heavily pigmented tumor. The brownish pigment obscured the morphology of the tumor cells that could not be visualized by conventional H&E stain. Bleached slides showed that tumor was composed of melanocytoma cells type I.
脉络膜黑色素细胞瘤是一种罕见的眼内肿瘤。有一些文献报道了原发性脉络膜和睫状体黑色素细胞瘤。据信,这些肿瘤中的大多数在临床上被诊断为痣或黑色素瘤,并分别进行随访或治疗而无需手术切除。一些临床特征可以为正确诊断提供线索。我们报告了一位 47 岁白人女性,她因 2 个月的渐进性视力丧失和右眼疼痛就诊。她右眼的视力仅能数指,为 3.0m,左眼视力为 20/20。右眼的眼前节检查显示 360 度后粘连,由于玻璃体混浊,眼底检查无法明确。左眼未见异常。眼压正常,双眼瞳孔反射存在。右眼的超声显示在锯齿缘水平的睫状体和前脉络膜有一个隆起的肿瘤。由于视力预后不良,主要考虑黑色素瘤,并建议进行眼球摘除术。右眼的大体和组织病理学检查显示一个色素沉着严重的肿瘤。棕色色素使肿瘤细胞的形态无法通过常规的 H&E 染色观察。漂白切片显示肿瘤由Ⅰ型黑色素细胞瘤细胞组成。