硫酸乙酰肝素蛋白聚糖与阿尔茨海默病神经原纤维缠结的关联。
Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease.
作者信息
Perry G, Siedlak S L, Richey P, Kawai M, Cras P, Kalaria R N, Galloway P G, Scardina J M, Cordell B, Greenberg B D
机构信息
Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio 44106.
出版信息
J Neurosci. 1991 Nov;11(11):3679-83. doi: 10.1523/JNEUROSCI.11-11-03679.1991.
The major intracytoplasmic lesion of Alzheimer's disease is the neurofibrillary tangle (NFT), which is primarily composed of paired helical filaments (PHFs). The mechanism responsible for the formation of PHFs, as well as their insolubility and apparent heterogeneity, is unknown. We found that basic fibroblast growth factor (bFGF) binds to heparinase-sensitive sites in NFTs. bFGF binding is due to a heparan sulfate proteoglycan (HSPG) immunocytochemically identified in NFTs. In the presence of polycations (e.g., Ca2+), HSPG will bind to free carboxyl groups in NFT proteins. HSPG binding may play a role in transforming normal soluble proteins into insoluble PHFs.
阿尔茨海默病主要的胞浆内病变是神经原纤维缠结（NFT），其主要由双螺旋丝（PHF）组成。负责PHF形成的机制，以及它们的不溶性和明显的异质性尚不清楚。我们发现碱性成纤维细胞生长因子（bFGF）与NFT中的肝素酶敏感位点结合。bFGF结合是由于在NFT中通过免疫细胞化学鉴定出的硫酸乙酰肝素蛋白聚糖（HSPG）。在多阳离子（如Ca2+）存在的情况下，HSPG会与NFT蛋白中的游离羧基结合。HSPG结合可能在将正常可溶性蛋白转化为不溶性PHF中起作用。
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