发炎的蜗牛加速转移。
Inflamed snail speeds metastasis.
作者信息
Yang Chih-Cheng, Wolf Dieter A
机构信息
Signal Transduction Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Cancer Cell. 2009 May 5;15(5):355-7. doi: 10.1016/j.ccr.2009.04.003.
Macrophage infiltration and inflammatory cytokines are powerful drivers of tumorigenesis and metastasis. Wu et al., in this issue of Cancer Cell, show that TNFalpha-dependent NFkappaB activation induces COP9 signalosome-mediated inhibition of GSK3beta and the SCF(beta-TRCP) ubiquitin ligase, thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis.
巨噬细胞浸润和炎性细胞因子是肿瘤发生和转移的强大驱动因素。吴等人在本期《癌细胞》杂志中表明，肿瘤坏死因子α依赖性核因子κB激活诱导COP9信号体介导的糖原合成酶激酶3β和SCF（β-转导素重复序列包含蛋白）泛素连接酶的抑制，从而导致转录因子Snail的稳定并促进细胞迁移和转移。
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