ADMA 通过 Wnt/β-catenin 信号通路介导胃癌细胞迁移和侵袭。
ADMA mediates gastric cancer cell migration and invasion via Wnt/β-catenin signaling pathway.
机构信息
Department of Oncological Surgery, The Second Affiliated Hospital of Fujian Medical University, 34 Zhongshanbei Road, Quanzhou, 362000, Fujian, China.
出版信息
Clin Transl Oncol. 2021 Feb;23(2):325-334. doi: 10.1007/s12094-020-02422-7. Epub 2020 Jun 30.
OBJECTIVE
To explore the role of ADMA in gastric cancer.
METHODS
The specimens of 115 gastric cancer patients were analyzed by ELISA and survival analysis. Functional assays were used to assess the effects of ADMA on gastric cancer cells. Experiments were conducted to detect the signaling pathway induced by ADMA in GC.
RESULTS
Gastric cancer patients with high ADMA levels had poor prognosis and low survival rate. Furthermore, high level of ADMA did not affect the proliferation while promoted the migration and invasion of gastric cancer cell. Moreover, ADMA enhanced the epithelial-mesenchymal transition (EMT). Importantly, ADMA positively regulated β-catenin expression in GC and promoted GC migration and invasion via Wnt/β-catenin pathway.
CONCLUSIONS
ADMA regulates gastric cancer cell migration and invasion via Wnt/β-catenin signaling pathway and which may be applied to clinical practice as a diagnostic and prognostic biomarker.
目的
探讨 ADMA 在胃癌中的作用。
方法
通过 ELISA 和生存分析对 115 例胃癌患者的标本进行分析。采用功能测定法评估 ADMA 对胃癌细胞的影响。实验检测 ADMA 在 GC 中诱导的信号通路。
结果
ADMA 水平高的胃癌患者预后不良，生存率低。此外，高水平的 ADMA 并不影响增殖，反而促进了胃癌细胞的迁移和侵袭。此外，ADMA 增强了上皮-间充质转化（EMT）。重要的是，ADMA 正向调节 GC 中的β-连环蛋白表达，并通过 Wnt/β-连环蛋白通路促进 GC 迁移和侵袭。
结论
ADMA 通过 Wnt/β-连环蛋白信号通路调节胃癌细胞的迁移和侵袭，可作为诊断和预后的生物标志物应用于临床实践。
Zotero 插件