Coen Paul M, Flynn Michael G, Markofski Melissa M, Pence Brandt D, Hannemann Robert E
Wastl Human Performance Laboratory, Purdue University, West Lafayette, IN 47907, USA.
Metabolism. 2009 Jul;58(7):1030-8. doi: 10.1016/j.metabol.2009.03.006.
Statin treatment and exercise training can improve lipid profile when administered separately. The efficacy of exercise and statin treatment combined, and its impact on myalgia and serum creatine kinase (CK) have not been completely addressed. The purpose of this study was to determine the effect of statin treatment and the addition of exercise training on lipid profile, including oxidized low-density lipoprotein (oxLDL), and levels of CK and alanine transaminase. Thirty-one hypercholesterolemic and physically inactive subjects were randomly assigned to rosuvastatin (R) or rosuvastatin/exercise (RE) group. A third group of physically active hypercholesterolemic subjects served as an active control group (AC). The R and RE groups received rosuvastatin treatment (10 mg/d) for 20 weeks. From week 10 to week 20, the RE group also participated in a combined endurance and resistive exercise training program (3 d/wk). Lipid profile was determined for all subjects at week 0 (Pre), week 10 (Mid), and week 20 (Post). The CK and alanine transaminase levels were measured at the same time points in the RE and R groups and 48 hours after the first and fifth exercise bout in the RE group. Each RE subject was formally queried about muscle fatigue, soreness, and stiffness before each training session. Total, LDL, and oxLDL cholesterol was lower in the RE and R groups at Mid and Post time points when compared with Pre. Oxidized LDL was lower in the RE group compared with the R group at the Post time point. When treatment groups (R and RE) were combined, high-density lipoprotein levels were increased and triglycerides decreased across time. Creatine kinase increased in the RE group 48 hours after the first exercise bout, but returned to baseline levels 48 hours after the fifth exercise bout. Rosuvastatin treatment decreased total, LDL, and oxLDL cholesterol. The addition of an exercise training program resulted in a further decrease in oxLDL. There was no abnormal sustained increase in CK or reports of myalgia after the addition of exercise training to rosuvastatin treatment.
单独使用他汀类药物治疗和运动训练均可改善血脂水平。运动与他汀类药物联合治疗的疗效及其对肌痛和血清肌酸激酶（CK）的影响尚未完全明确。本研究旨在确定他汀类药物治疗以及联合运动训练对血脂水平（包括氧化型低密度脂蛋白（oxLDL））、CK水平和丙氨酸转氨酶水平的影响。31名高胆固醇血症且缺乏运动的受试者被随机分为瑞舒伐他汀（R）组或瑞舒伐他汀/运动（RE）组。第三组有运动习惯的高胆固醇血症受试者作为活性对照组（AC）。R组和RE组接受瑞舒伐他汀治疗（10mg/天），持续20周。从第10周到第20周，RE组还参加了耐力和阻力相结合的运动训练项目（每周3天）。在第0周（基线）、第10周（中期）和第20周（后期）测定所有受试者的血脂水平。在RE组和R组的相同时间点以及RE组第一次和第五次运动后48小时测量CK和丙氨酸转氨酶水平。每次训练前，对每位RE组受试者进行肌肉疲劳、酸痛和僵硬情况的正式询问。与基线相比，RE组和R组在中期和后期的总胆固醇、低密度脂蛋白胆固醇和oxLDL胆固醇水平较低。在后期时间点，RE组的氧化型低密度脂蛋白低于R组。当合并治疗组（R组和RE组）时，高密度脂蛋白水平随时间增加，甘油三酯水平降低。RE组在第一次运动后48小时CK升高，但在第五次运动后48小时恢复到基线水平。瑞舒伐他汀治疗可降低总胆固醇、低密度脂蛋白胆固醇和oxLDL胆固醇。增加运动训练项目导致oxLDL进一步降低。在瑞舒伐他汀治疗基础上增加运动训练后，CK没有异常持续升高，也没有肌痛报告。
