Anandakumar Pandi, Kamaraj Sattu, Ramakrishnan Gopalakrishnan, Jagan Sundaram, Devaki Thiruvengadam
Department of Biochemistry, University of Madras, Guindy Campus, Chennai, Tamil Nadu, India.
Basic Clin Pharmacol Toxicol. 2009 May;104(5):360-5. doi: 10.1111/j.1742-7843.2009.00387.x.
A voluminous number of evidence suggests that an increased consumption of fruits and vegetables is a relatively easy and practical strategy to reduce significantly the incidence of cancer. The present study is an effort to identify the chemopreventive role of alkaloid capsaicin against benzo(a)pyrene-induced lung cancer in Swiss albino mice. Benzo(a)pyrene-induced lung cancer-bearing animals showed abnormal changes in body weight, lung weight, tumour incidence and alterations in the activities of marker enzymes adenosine deaminase, aryl hydrocarbon hydroxylase, gamma-glutamyl transpeptidase, 5'-nucleotidase and lactate dehydrogenase. On capsaicin pre-co-treatment, all the above alterations were returned to near normal. Immunohistochemical analysis of proliferating cell nuclear antigen together with lung histological examination further supported our biochemical findings that demonstrated the chemoprotective role of capsaicin against benzo(a)pyrene-induced experimental lung cancer.
大量证据表明，增加水果和蔬菜的摄入量是一种相对容易且切实可行的策略，可显著降低癌症发病率。本研究旨在确定生物碱辣椒素对苯并(a)芘诱导的瑞士白化小鼠肺癌的化学预防作用。苯并(a)芘诱导的荷肺癌动物在体重、肺重量、肿瘤发生率以及标记酶腺苷脱氨酶、芳烃羟化酶、γ-谷氨酰转肽酶、5'-核苷酸酶和乳酸脱氢酶的活性方面出现了异常变化。经过辣椒素预处理后，上述所有变化均恢复至接近正常水平。增殖细胞核抗原的免疫组织化学分析以及肺组织学检查进一步支持了我们的生化研究结果，即证明了辣椒素对苯并(a)芘诱导的实验性肺癌具有化学保护作用。
