Rabiau Nadege, Dechelotte Pierre, Guy Laurent, Satih Samir, Bosviel Remy, Fontana Luc, Kemeny Jean-Louis, Boiteux Jean-Paul, Bignon Yves-Jean, Bernard-Gallon Dominique
Département d'Oncogénétique du Centre Jean Perrin, Occupational Health Institute, CHU, 58 rue Montalembert, B.P.392, 63011 Clermont-Ferrand Cedex 01, France.
In Vivo. 2009 Mar-Apr;23(2):203-7.
Prostate cancer is a major public health problem in the world. Molecular studies are necessary for the development of prognostic markers in prostate cancer. There is a great interest in mucin studies in treatment development of human malignancies, including prostate cancer. Nevertheless, their expressions in prostate cancer need further investigation.
Mucin 1 (MUC1) expression was examined in 100 prostate biopsies and were compared with prostate carcinoma cell lines (DU-145, PC-3, LNCaP) by immunohistochemistry.
Biopsies were healthy, tumor, peritumor or presented an intraepithelial neoplasia. Staining of MUC1 was exihibited in PC-3 cells, was higher in DU-145, and was not expressed by LNCaP. Tumor sections presented more positive expression of MUC1 than non-tumor sections.
MUC1 expression is correlated with the histological degree of malignancy.
前列腺癌是全球主要的公共卫生问题。分子研究对于前列腺癌预后标志物的开发至关重要。在包括前列腺癌在内的人类恶性肿瘤治疗开发中，黏蛋白研究备受关注。然而，它们在前列腺癌中的表达仍需进一步研究。
通过免疫组织化学检测了100份前列腺活检组织中的黏蛋白1（MUC1）表达，并与前列腺癌细胞系（DU-145、PC-3、LNCaP）进行比较。
活检组织为健康、肿瘤、肿瘤周围或上皮内瘤变。MUC1在PC-3细胞中呈阳性染色，在DU-145中更高，而LNCaP未表达。肿瘤切片中MUC1的阳性表达多于非肿瘤切片。
MUC1表达与恶性组织学程度相关。
