Takeuchi F, Takeuchi A
Department of Internal Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Japan.
J Rheumatol. 1991 Aug;18(8):1207-10.
Peripheral lymphocytes from 14 patients with Behçet's disease (BD) were examined for frequencies of chromosomal aberration. The frequency of gaps and breaks were not high in patients with BD but the frequency of dicentrics was increased in patients treated with colchicine or anticancer medicines. Patients treated with neither colchicine nor anticancer medicines showed no increased frequency of dicentrics. Our data suggested that the effect of treatment with colchicine or anticancer medication was one of the causes of the chromosome aberration observed in some BD lymphocytes. No numerical abnormality was observed in BD lymphocytes.
对14例白塞病（BD）患者的外周淋巴细胞进行染色体畸变频率检测。BD患者的裂隙和断裂频率不高，但使用秋水仙碱或抗癌药物治疗的患者双着丝粒频率增加。未使用秋水仙碱和抗癌药物治疗的患者双着丝粒频率未增加。我们的数据表明，秋水仙碱或抗癌药物治疗的影响是部分BD淋巴细胞中观察到的染色体畸变的原因之一。BD淋巴细胞未观察到数目异常。
