Diadyk A I, Sokhin A A, Siniachenko O V, Efremenko V A, Bagriĭ A E, Nikolenko Iu I, Iarovaia N F, Nikolenko V Iu
Vrach Delo. 1990 Sep(9):47-9.
The levels of aberration of chromosomes in peripheral blood leucocytes were investigated in patients with chronic and lupoid glomerulonephritis considering the clinical variants and morphological forms of the disease. In chronic glomerulonephritis high levels of chromosome aberration were found in patients with nephrotic type; in lupoid glomerulonephritis the frequency of chromosome aberration was higher in patients with active glomerulonephritis. Chronic renal failure did not essentially change the level of chromosome aberration both in chronic and lupoid glomerulonephritis. In different morphological forms of glomerulonephritis the frequency of chromosome aberration was determined by the clinical variant of the disease.
考虑到慢性和类狼疮性肾小球肾炎的临床变体和形态学形式，对这些疾病患者外周血白细胞中的染色体畸变水平进行了研究。在慢性肾小球肾炎中，肾病型患者的染色体畸变水平较高；在类狼疮性肾小球肾炎中，活动性肾小球肾炎患者的染色体畸变频率较高。慢性肾衰竭在慢性和类狼疮性肾小球肾炎中均未实质性改变染色体畸变水平。在不同形态学形式的肾小球肾炎中，染色体畸变频率由疾病的临床变体决定。
