Department of Dermatology, Hospital Juan Canalejo, La Coruña, Spain.
J Dermatolog Treat. 2010 Jan;21(1):49-53. doi: 10.3109/09546630902887203.
Actinic cheilitis (AC) is a precancerous lesion of the lip. Treatment of AC is indicated for prevention of squamous cell carcinoma (SCC), although the exact transition rate of AC to SCC is unknown. Carbon dioxide (CO(2)) laser vaporization seems to be an adequate therapy for AC, but there are no references about the evolution rate of AC to SCC after this treatment.
To evaluate the results obtained after treatment of AC by CO(2) laser vaporization in comparison with other treatment modalities and the evolution rate of AC to SCC after CO(2) laser treatment.
A retrospective review identified 43 patients with AC treated with CO(2) laser vaporization at our hospital from 2002 to 2006. Clinical and therapeutic information was evaluated. All patients were followed for more than 15 months after treatment.
After a mean follow-up period of 29.4 months, 3/43 treated AC showed local recurrence. Another two patients developed SCC in the treated field. A residual scar was clinically evident in two patients.
CO(2) laser vaporization with an adequate postoperative follow-up is an effective treatment for chronic AC. Nevertheless, some patients (4,6%) went on to develop lip SCC. The follow-up of these patients is mandatory.
光化性唇炎（AC）是唇部的癌前病变。治疗 AC 的目的是预防鳞状细胞癌（SCC），尽管 AC 向 SCC 的确切转化率尚不清楚。二氧化碳（CO 2 ）激光汽化似乎是治疗 AC 的一种合适的疗法，但关于 CO 2 激光治疗后 AC 向 SCC 的演变率尚无参考。
评估 CO 2 激光汽化治疗 AC 的结果，并与其他治疗方法进行比较，以及 CO 2 激光治疗后 AC 向 SCC 的演变率。
回顾性分析了 2002 年至 2006 年在我院接受 CO 2 激光汽化治疗的 43 例 AC 患者。评估了临床和治疗信息。所有患者在治疗后均随访超过 15 个月。
在平均随访 29.4 个月后，3/43 例治疗的 AC 出现局部复发。另外两名患者在治疗部位发生 SCC。两名患者的残留瘢痕在临床上明显。
CO 2 激光汽化治疗并进行适当的术后随访是治疗慢性 AC 的有效方法。然而，一些患者（4.6%）仍发展为唇 SCC。这些患者的随访是强制性的。
