Hansen R M, Varma R R, Hanson G A
Department of Medicine, Medical College of Wisconsin, Milwaukee 53226.
J Rheumatol. 1991 Aug;18(8):1251-3.
A 54-year-old man developed severe cholestatic jaundice and pure red cell aplasia shortly after beginning treatment with gold sodium thiomalate. Although the hepatic toxicity began to spontaneously improve, the pure red cell aplasia was progressive. Treatment with prednisone and N-acetylcysteine (NAC) infusions was followed by prompt and complete hematologic recovery. Gold induced pure red cell aplasia should be added to the list of gold induced hematologic toxicities that can be potentially reversed with NAC infusion therapy.
一名54岁男性在开始接受硫代苹果酸金钠治疗后不久出现严重胆汁淤积性黄疸和纯红细胞再生障碍。尽管肝毒性开始自发改善，但纯红细胞再生障碍仍在进展。使用泼尼松和N-乙酰半胱氨酸（NAC）输注治疗后，血液学迅速完全恢复。金诱导的纯红细胞再生障碍应列入可通过NAC输注疗法潜在逆转的金诱导血液学毒性清单中。
