Godfrey N F, Peter A, Simon T M, Lorber A
J Rheumatol. 1982 Jul-Aug;9(4):519-26.
Twelve patients with adverse hematologic reactions to chrysotherapy received intravenous N-acetylcysteine (IV NAC) to achieve removal and/or redistribution of gold. Urine gold excretion while on IV NAC doubled that predicted from control measurements. Treatment within 20 days of the last gold injection was associated with better recovery of hematologic parameters. No untoward reactions from IV NAC were encountered. The pathogenesis of gold induced hematologic reactions is examined from both toxic as well as immunological perspectives.
12名接受金疗法后出现不良血液学反应的患者接受了静脉注射N-乙酰半胱氨酸（IV NAC），以实现金的清除和/或重新分布。接受IV NAC治疗时的尿金排泄量是对照测量预测值的两倍。在最后一次注射金后的20天内进行治疗与血液学参数的更好恢复相关。未遇到IV NAC的不良反应。从毒性和免疫两个角度研究了金诱导血液学反应的发病机制。
