一名中性粒细胞减少患者发生由耐达托霉素杰氏棒状杆菌引起的危及生命的感染。
Life-threatening infection caused by daptomycin-resistant Corynebacterium jeikeium in a neutropenic patient.
作者信息
Schoen Christoph, Unzicker Christian, Stuhler Gernot, Elias Johannes, Einsele Hermann, Grigoleit Götz Ulrich, Abele-Horn Marianne, Mielke Stephan
机构信息
Institute for Hygiene and Microbiology, Julius Maximilian University, Würzburg, Germany.
出版信息
J Clin Microbiol. 2009 Jul;47(7):2328-31. doi: 10.1128/JCM.00457-09. Epub 2009 May 6.
Abstract
Daptomycin is a novel lipopeptide antibiotic agent approved for the treatment of gram-positive life-threatening infections. Here we report, for the first time, the isolation of a highly daptomycin-resistant strain of Corynebacterium jeikeium causing a life-threatening infection in a neutropenic patient undergoing cord blood transplantation for secondary acute myeloid leukemia.
摘要
达托霉素是一种新型脂肽类抗生素，已被批准用于治疗革兰氏阳性菌引起的危及生命的感染。在此，我们首次报告从一名因继发性急性髓系白血病接受脐血移植的中性粒细胞减少患者中分离出一株对达托霉素高度耐药的杰氏棒状杆菌，该菌株引起了危及生命的感染。
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Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora.多耐药医院病原体杰氏棒状杆菌K411的全基因组序列测定与分析，该菌是一种需要脂质的人体皮肤菌群细菌。
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