Scientific and Technological Bioresource Nucleus (BIOREN), Universidad de La Frontera, Temuco 4811230, Chile.
Carrera de Bioquímica, Departamento de Ciencias Químicas y Recursos Naturales, Universidad de La Frontera, Temuco 4811230, Chile.
Int J Mol Sci. 2021 Jul 13;22(14):7499. doi: 10.3390/ijms22147499.
, a bacterium that is part of the normal skin microbiota, is also an opportunistic pathogen. In recent years, reports of infections and in-hospital and nosocomial outbreaks caused by antimicrobial multidrug-resistant strains have been increasing worldwide. However, there are no studies about the genomic determinants related to antimicrobial resistance in . This review updates global information related to antimicrobial resistance found in and highlights the essential genomic aspects in its persistence and dissemination. The resistome of comprises chromosomal and acquired elements. Resistance to fluoroquinolones and daptomycin are due to mutations in chromosomal genes. Conversely, resistance to macrolides, tetracyclines, phenicols, beta-lactams, and aminoglycosides are associated with mobile genomic elements such as plasmids and transposons. The presence and diversity of insertion sequences suggest an essential role in the expression of antimicrobial resistance genes (ARGs) in genomic rearrangements and their potential to transfer these elements to other pathogens. The present study underlines that the resistome of is dynamic; it is in evident expansion and could be acting as a reservoir for ARGs.
作为正常皮肤微生物群的一部分，也是一种机会性病原体。近年来，由抗微生物多药耐药菌株引起的感染以及医院内和医院获得性暴发的报告在全球范围内不断增加。然而，关于 中与抗微生物药物耐药性相关的基因组决定因素的研究尚不多见。本综述更新了 中发现的抗微生物药物耐药性的全球信息，并强调了其持续存在和传播的重要基因组方面。 的耐药组由染色体和获得性元件组成。对氟喹诺酮类和达托霉素的耐药性是由于染色体基因的突变引起的。相反，对大环内酯类、四环素类、酚类、β-内酰胺类和氨基糖苷类的耐药性与质粒和转座子等可移动基因组元件有关。插入序列的存在和多样性表明其在基因组重排中对抗微生物药物耐药基因 (ARGs) 的表达以及将这些元件转移到其他病原体中的重要作用。本研究强调， 的耐药组是动态的；它正在明显扩张，并可能成为 ARGs 的储库。
