一种高效的一锅法铜催化制备异喹啉-1(2H)-酮衍生物的方法。
An efficient one-pot copper-catalyzed approach to isoquinolin-1(2H)-one derivatives.
作者信息
Wang Feng, Liu Hongxia, Fu Hua, Jiang Yuyang, Zhao Yufen
机构信息
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
出版信息
Org Lett. 2009 Jun 4;11(11):2469-72. doi: 10.1021/ol900847t.
PMID:19422263
Abstract
A simple and efficient copper-catalyzed method for synthesis of 3,4-disubstituted isoquinolin-1(2H)-one derivatives via cascade reactions of substituted 2-halobenzamides with beta-keto esters under mild conditions has been developed, and the method has economical and practical advantages.
摘要
已开发出一种简单高效的铜催化方法，用于在温和条件下通过取代的2-卤代苯甲酰胺与β-酮酯的级联反应合成3,4-二取代异喹啉-1(2H)-酮衍生物，该方法具有经济实用的优点。
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