镍催化 2-卤代苯甲酰胺与炔烃的环化反应合成高取代异喹啉衍生物。
Synthesis of highly substituted isoquinolone derivatives by nickel-catalyzed annulation of 2-halobenzamides with alkynes.
机构信息
Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan.
出版信息
Org Lett. 2010 Aug 6;12(15):3518-21. doi: 10.1021/ol101371c.
PMID:20608667
Abstract
An efficient method for the synthesis of substituted 1(2H)-isoquinolone derivatives via nickel-catalyzed annulation of substituted 2-halobenzamides with alkynes is described. This protocol is successfully applied to the total synthesis of oxyavicine with excellent yield.
摘要
一种通过镍催化取代的 2-卤代苯甲酰胺与炔烃的环化反应合成取代的 1(2H)-异喹啉酮衍生物的有效方法被描述。该方案成功地应用于氧代阿维辛的全合成，产率优异。
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