Diabetes Obes Metab. 2009 May;11(5):516-8. doi: 10.1111/j.1463-1326.2008.00979.x.
To investigate the reproducibility of measurements of hepatic triglyceride content (HTGC) in subjects with normal HTGC using localized (1)H-magnetic resonance spectroscopy ((1)H-MRS) and a clinical 1.5T scanner.
The (1)H-MRS acquisition was performed with a common protocol using the whole-body coil and no respiratory triggering. An upper limit of normal HTGC of 5.56% was used. Duplicate measurements, including subject repositioning, were acquired from 23 subjects, 19 of whom had a normal HTGC.
The mean coefficient of variation (CV) from the duplicate measurements was 14.8% (20.5% before exclusion of a subject who was considered to be an outlier). Mean CVs of subgroups below and above the 1% HTGC limit were 19.8 and 7.0 respectively.
The mean CV calculated in subjects with HTGC in the normal range was found to be higher than CVs of wide range HTGC groups reported in the literature. It is concluded that the reproducibility of HTGC measurements using (1)H-MRS depends on the HTGC range. These findings are of importance in reproducibility studies and in estimations of required study group sizes.
使用局部（1）H 磁共振波谱（（1）H-MRS）和临床 1.5T 扫描仪，研究正常肝甘油三酯含量（HTGC）受试者 HTGC 测量的可重复性。
采用全身线圈和无呼吸触发的常用方案进行（1）H-MRS 采集。使用上限为 5.56%的正常 HTGC。从 23 名受试者中采集了重复测量，包括重新定位受试者，其中 19 名受试者的 HTGC 正常。
重复测量的平均变异系数（CV）为 14.8%（排除被认为是异常值的受试者后为 20.5%）。低于和高于 1%HTGC 限值的亚组的平均 CV 分别为 19.8%和 7.0%。
在 HTGC 正常范围内的受试者中计算出的平均 CV 高于文献中报告的 HTGC 范围较宽的组的 CV。结论是，（1）H-MRS 测量 HTGC 的可重复性取决于 HTGC 范围。这些发现对于可重复性研究和估计所需的研究组大小很重要。
Zotero 插件