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Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.
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Swi1 and Swi3 are components of a replication fork protection complex in fission yeast.
Mol Cell Biol. 2004 Oct;24(19):8342-55. doi: 10.1128/MCB.24.19.8342-8355.2004.
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Swi1 associates with chromatin through the DDT domain and recruits Swi3 to preserve genomic integrity.
PLoS One. 2012;7(8):e43988. doi: 10.1371/journal.pone.0043988. Epub 2012 Aug 30.
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Hsk1 kinase and Cdc45 regulate replication stress-induced checkpoint responses in fission yeast.
Cell Cycle. 2010 Dec 1;9(23):4627-37. doi: 10.4161/cc.9.23.13937.
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Checkpoint-Independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 Kinase.
Mol Cell Biol. 2017 Mar 17;37(7). doi: 10.1128/MCB.00355-16. Print 2017 Apr 1.

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Keeping it safe: control of meiotic chromosome breakage.
Trends Genet. 2025 Apr;41(4):315-329. doi: 10.1016/j.tig.2024.11.006. Epub 2024 Dec 12.
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The fork protection complex generates DNA topological stress-induced DNA damage while ensuring full and faithful genome duplication.
Proc Natl Acad Sci U S A. 2024 Dec 3;121(49):e2413631121. doi: 10.1073/pnas.2413631121. Epub 2024 Nov 26.
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A replisome-associated histone H3-H4 chaperone required for epigenetic inheritance.
Cell. 2024 Sep 5;187(18):5010-5028.e24. doi: 10.1016/j.cell.2024.07.006. Epub 2024 Aug 1.
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The fork protection complex promotes parental histone recycling and epigenetic memory.
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Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defect.
Life Sci Alliance. 2023 Feb 7;6(4). doi: 10.26508/lsa.202201603. Print 2023 Apr.
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The Fork Protection Complex: A Regulatory Hub at the Head of the Replisome.
Subcell Biochem. 2022;99:83-107. doi: 10.1007/978-3-031-00793-4_3.
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Characterisation of unessential genes required for survival under conditions of DNA stress.
J Genet Eng Biotechnol. 2020 May 6;18(1):14. doi: 10.1186/s43141-020-00025-x.
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Overlapping Roles in Chromosome Segregation for Heterochromatin Protein 1 (Swi6) and DDK in .
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本文引用的文献

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Cdc7 kinase mediates Claspin phosphorylation in DNA replication checkpoint.
Oncogene. 2008 May 29;27(24):3475-82. doi: 10.1038/sj.onc.1210994. Epub 2007 Dec 17.
2
The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement.
Mol Cell Biol. 2007 Apr;27(8):3131-42. doi: 10.1128/MCB.02190-06. Epub 2007 Feb 12.
3
Tipin and Timeless form a mutually protective complex required for genotoxic stress resistance and checkpoint function.
Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18143-7. doi: 10.1073/pnas.0609251103. Epub 2006 Nov 20.
4
Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint.
J Biol Chem. 2007 Jan 26;282(4):2729-40. doi: 10.1074/jbc.M605596200. Epub 2006 Nov 13.
5
Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.
J Biol Chem. 2006 Dec 22;281(51):39249-61. doi: 10.1074/jbc.M608935200. Epub 2006 Oct 17.
6
Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery.
Curr Biol. 2006 Oct 10;16(19):1950-5. doi: 10.1016/j.cub.2006.08.026. Epub 2006 Aug 24.
10
Hsk1 kinase is required for induction of meiotic dsDNA breaks without involving checkpoint kinases in fission yeast.
Proc Natl Acad Sci U S A. 2006 May 23;103(21):8131-6. doi: 10.1073/pnas.0602498103. Epub 2006 May 12.

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